Open Access

Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review)

  • Authors:
    • Wenlu Zhang
    • Wen Wen
    • Ran Tan
    • Meirui Zhang
    • Tantan Zhong
    • Jianhong Wang
    • Haiping Chen
    • Xiaosheng Fang
  • View Affiliations

  • Published online on: September 30, 2024     https://doi.org/10.3892/ol.2024.14707
  • Article Number: 574
  • Copyright : © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Ferroptosis is a relatively recently discovered type of regulated cell death that is induced by iron‑dependent lipid peroxidation. The key contributing factors to ferroptosis are the loss of glutathione peroxidase 4 which is required for reversing lipid peroxidation, the buildup of redox‑active iron and the oxidation of phospholipids containing polyunsaturated fatty acids. Ferroptosis has been associated with a number of diseases, including cancers such as hepatocellular carcinoma, breast cancer, acute renal damage and neurological disorders such as Alzheimer's disease and Alzheimer's disease, and there may be an association between ferroptosis and acute myeloid leukemia (AML). The present review aims to describe the primary regulatory pathways of ferroptosis, and the relationship between ferroptosis and the occurrence and development of AML. Furthermore, the present review comprehensively summarizes the latest advances in the treatment and prognosis of ferroptosis in AML.
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December-2024
Volume 28 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang W, Wen W, Tan R, Zhang M, Zhong T, Wang J, Chen H and Fang X: Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review). Oncol Lett 28: 574, 2024.
APA
Zhang, W., Wen, W., Tan, R., Zhang, M., Zhong, T., Wang, J. ... Fang, X. (2024). Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review). Oncology Letters, 28, 574. https://doi.org/10.3892/ol.2024.14707
MLA
Zhang, W., Wen, W., Tan, R., Zhang, M., Zhong, T., Wang, J., Chen, H., Fang, X."Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review)". Oncology Letters 28.6 (2024): 574.
Chicago
Zhang, W., Wen, W., Tan, R., Zhang, M., Zhong, T., Wang, J., Chen, H., Fang, X."Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review)". Oncology Letters 28, no. 6 (2024): 574. https://doi.org/10.3892/ol.2024.14707