Open Access

Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review

  • Authors:
    • Nicky Somers
    • Emma Butaye
    • Lorenz Grossar
    • Nele Pauwels
    • Anja Geerts
    • Sarah Raevens
    • Sander Lefere
    • Lindsey Devisscher
    • Leander Meuris
    • Nico Callewaert
    • Hans Van Vlierberghe
    • Xavier Verhelst
  • View Affiliations

  • Published online on: October 23, 2024     https://doi.org/10.3892/ol.2024.14769
  • Article Number: 24
  • Copyright: © Somers et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, which is associated with a low 5‑year survival rate. The importance of effective disease monitoring and prognostic evaluation is undeniable. For the present study, a systematic review was performed using extensive searches in Medline, Embase, Web of Science and Scopus up to December 29, 2023. The aim of the present study was to examine whether N‑glycomics could predict the risk of developing HCC in adults with chronic liver disease and, if HCC was present, predict overall survival. As a secondary outcome, the prediction capability of HCC recurrence was assessed. After deduplication, 3,904 studies were identified, of which 30 were included. Overall, the median size of the study cohort was 144 patients, with a median follow‑up time of 63.6 months. Three studies explored N‑glycomics in whole serum, whereas the rest focused on individual glycoproteins, with Mac‑2 binding protein glycosylation isomer (M2BPGi) being the most commonly studied. Most articles investigated baseline M2BPGi values as predictors for the development of HCC and demonstrated a median area under the curve of 0.83 with a cut‑off index value of 1.8. In conclusion, it was revaled that N‑glycan changes exhibit added value in determining patient prognosis in terms of survival, monitoring HCC development and recurrence.
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January-2025
Volume 29 Issue 1

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Spandidos Publications style
Somers N, Butaye E, Grossar L, Pauwels N, Geerts A, Raevens S, Lefere S, Devisscher L, Meuris L, Callewaert N, Callewaert N, et al: Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review. Oncol Lett 29: 24, 2025.
APA
Somers, N., Butaye, E., Grossar, L., Pauwels, N., Geerts, A., Raevens, S. ... Verhelst, X. (2025). Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review. Oncology Letters, 29, 24. https://doi.org/10.3892/ol.2024.14769
MLA
Somers, N., Butaye, E., Grossar, L., Pauwels, N., Geerts, A., Raevens, S., Lefere, S., Devisscher, L., Meuris, L., Callewaert, N., Van Vlierberghe, H., Verhelst, X."Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review". Oncology Letters 29.1 (2025): 24.
Chicago
Somers, N., Butaye, E., Grossar, L., Pauwels, N., Geerts, A., Raevens, S., Lefere, S., Devisscher, L., Meuris, L., Callewaert, N., Van Vlierberghe, H., Verhelst, X."Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review". Oncology Letters 29, no. 1 (2025): 24. https://doi.org/10.3892/ol.2024.14769