Open Access

Ultrasound combined with contrast‑enhanced ultrasound in the diagnosis of primary squamous cell carcinoma of the thyroid: A case report and literature review

  • Authors:
    • Cuie Chen
    • Qiuxiao Xu
    • Yijing Deng
    • Jianling Peng
    • Xueling He
    • Lijuan Liu
  • View Affiliations

  • Published online on: January 7, 2025     https://doi.org/10.3892/ol.2025.14877
  • Article Number: 131
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare malignancy with a poor prognosis. Therefore, early diagnosis and treatment are critical to the survival of patients and to improve their quality of life. However, diagnosing this illness is challenging. The present study describes the ultrasound (US) and contrast‑enhanced US (CEUS) findings of PSCCT diagnosed in a 69‑year‑old woman with a rapidly enlarging neck mass. A total thyroidectomy was performed, and the results of postoperative pathology and immunohistochemical tests confirmed the diagnosis of PSCCT. Any other potential primary tumor site was excluded. This case and literature review provide a reliable reference for the diagnosis of PSCCT using US combined with CEUS. Radiologists should increase their understanding of this disease to achieve an early and accurate diagnosis.
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March-2025
Volume 29 Issue 3

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Spandidos Publications style
Chen C, Xu Q, Deng Y, Peng J, He X and Liu L: Ultrasound combined with contrast‑enhanced ultrasound in the diagnosis of primary squamous cell carcinoma of the thyroid: A case report and literature review. Oncol Lett 29: 131, 2025.
APA
Chen, C., Xu, Q., Deng, Y., Peng, J., He, X., & Liu, L. (2025). Ultrasound combined with contrast‑enhanced ultrasound in the diagnosis of primary squamous cell carcinoma of the thyroid: A case report and literature review. Oncology Letters, 29, 131. https://doi.org/10.3892/ol.2025.14877
MLA
Chen, C., Xu, Q., Deng, Y., Peng, J., He, X., Liu, L."Ultrasound combined with contrast‑enhanced ultrasound in the diagnosis of primary squamous cell carcinoma of the thyroid: A case report and literature review". Oncology Letters 29.3 (2025): 131.
Chicago
Chen, C., Xu, Q., Deng, Y., Peng, J., He, X., Liu, L."Ultrasound combined with contrast‑enhanced ultrasound in the diagnosis of primary squamous cell carcinoma of the thyroid: A case report and literature review". Oncology Letters 29, no. 3 (2025): 131. https://doi.org/10.3892/ol.2025.14877