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Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma

  • Authors:
    • Bo Lin
    • Yuling Chen
    • Xiaolian Li
    • Yuntao Lin
    • Jian Zhou
    • Hongyu Yang
    • Yuehong Shen

  • View Affiliations

  • Published online on: January 24, 2025     https://doi.org/10.3892/ol.2025.14906
  • Article Number: 160

  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment.

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March-2025
Volume 29 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Lin B, Chen Y, Li X, Lin Y, Zhou J, Yang H and Shen Y: Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncol Lett 29: 160, 2025.
APA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., & Shen, Y. (2025). Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma. Oncology Letters, 29, 160. https://doi.org/10.3892/ol.2025.14906
MLA
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29.3 (2025): 160.
Chicago
Lin, B., Chen, Y., Li, X., Lin, Y., Zhou, J., Yang, H., Shen, Y."Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma". Oncology Letters 29, no. 3 (2025): 160. https://doi.org/10.3892/ol.2025.14906