Open Access

A rare case of hyalinizing clear cell carcinoma of the tongue root: A case report and literature review

  • Authors:
    • Langqing Liu
    • Xue Cao
    • Yingjie Xu
    • Jie Wang
    • Xiao Tian
    • Yulian Fu
    • Bin Ling
  • View Affiliations

  • Published online on: February 4, 2025     https://doi.org/10.3892/ol.2025.14914
  • Article Number: 168
  • Copyright : © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study describes a rare case of hyalinizing clear cell carcinoma (HCCC) of the tongue root and provides an analysis and review of the relevant literature to improve the understanding of its diagnosis and treatment. Clinical imaging and pathological data from a patient with primary HCCC of the tongue root were summarized, and previously published studies were reviewed through a literature search. The common symptoms, treatment strategies and prognoses reported in the literature were compared. A total of 16 cases of primary HCCC of the tongue were retrieved. Histologically, these cases had tumors characterized by clear cells arranged in sheets, nests and cords within the fibrous interstitium surrounding tumor cells, with round to oval cell nuclei occasionally containing small or inconspicuous nucleoli. Immunohistochemistry showed positive tumor cell staining for cytokeratin (CK)5/6, CK7 and p63, and negative for S‑100, smooth muscle actin and calponin. Clinical symptoms included dysphagia, a painless mass, tongue root ulceration and a foreign body sensation in the throat. Treatment strategies included surgery, radiation therapy, repair and reconstruction, with no local recurrence or metastasis at any follow‑up point. The present findings indicated that HCCC of the salivary glands is an inert malignant tumor, and a good prognosis can be achieved with both surgical resection and radiation therapy.
View Figures
View References

Related Articles

Journal Cover

April-2025
Volume 29 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Cao X, Xu Y, Wang J, Tian X, Fu Y and Ling B: A rare case of hyalinizing clear cell carcinoma of the tongue root: A case report and literature review. Oncol Lett 29: 168, 2025.
APA
Liu, L., Cao, X., Xu, Y., Wang, J., Tian, X., Fu, Y., & Ling, B. (2025). A rare case of hyalinizing clear cell carcinoma of the tongue root: A case report and literature review. Oncology Letters, 29, 168. https://doi.org/10.3892/ol.2025.14914
MLA
Liu, L., Cao, X., Xu, Y., Wang, J., Tian, X., Fu, Y., Ling, B."A rare case of hyalinizing clear cell carcinoma of the tongue root: A case report and literature review". Oncology Letters 29.4 (2025): 168.
Chicago
Liu, L., Cao, X., Xu, Y., Wang, J., Tian, X., Fu, Y., Ling, B."A rare case of hyalinizing clear cell carcinoma of the tongue root: A case report and literature review". Oncology Letters 29, no. 4 (2025): 168. https://doi.org/10.3892/ol.2025.14914