Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report

Deng,Xiaofei; Luo,Yong; Yang,Qin; Chen,Bian; Peng,Wei; Zheng,Jincheng; Xiu,Weigang

doi:10.3892/ol.2025.14958

Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report

Authors:
- Xiaofei Deng
- Yong Luo
- Qin Yang
- Bian Chen
- Wei Peng
- Jincheng Zheng
- Weigang Xiu
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Affiliations: Department of Oncology, Yingshan County People's Hospital, Nanchong, Sichuan 637000, P.R. China, Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321099, P.R. China, Department of Thoracic Oncology and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: March 4, 2025 https://doi.org/10.3892/ol.2025.14958
Article Number: 212
Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Primary gingival diffuse large B‑cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49‑year‑old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw. Computed tomography revealed a mass in the gingiva, and enlarged lymph nodes in the cervical, mediastinal and gastro‑hepatic ligaments. Histological examination indicated the gingival mass was a DLBCL, which was positive for CD20, BCL‑6, BCL‑2, C‑MYC and MUM1. The patient received three lines of anti‑neoplastic therapy (R‑CHOP, R‑CHOEP and SYHX1903) and achieved stable disease for 6 years. Subsequently, the patient experienced trauma in the left forearm due to a car accident and the subsequent color Doppler imaging led to a diagnosis of muscular hematoma; however, magnetic resonance imaging and biopsy of the forearm muscle confirmed DLBCL invasion. Due to the patient suffering from heart failure after the third line of the previous chemotherapy, palliative radiotherapy was administered to the left forearm, and the patient achieved a partial response. In conclusion, primary gingival DLBCL with muscle invasion is rare and easily misdiagnosed, and individualized treatment should be considered for these complex cases.

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