Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2025 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation

  • Authors:
    • Yuxia Wang
    • Wei Wang
    • Dan Zheng
    • Ying Gao
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China, Department of Gynecology, Harbin Red Cross Central Hospital, Harbin, Heilongjiang 150076, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 255
    |
    Published online on: April 1, 2025
       https://doi.org/10.3892/ol.2025.15001
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Exosomes can be used to mediate the delivery of nucleic acids such as microRNA‑125b‑5p (miR‑125b‑5p), a tumor‑suppressor in certain types of cancer, into tumor cells. The present study investigated the use of bone mesenchymal stem cells‑derived exosome (BMSCs‑Exo) delivery of miR‑125b‑5p in ovarian cancer (OC). BMSCs were transfected with miR‑125b‑5p mimic, from which exosomes termed Exo‑miR‑125b‑5p mimic were extracted. The expression levels of miR‑125b‑5p in OC tissue samples, BMSCs, exosomes and SKOV3 cells were quantified using reverse transcription‑quantitative PCR. The influence of Exo‑miR‑125b‑5p mimic on the biological functions of OC was evaluated through cell proliferation, invasion, migration and apoptosis assays. The targeting relationship between miR‑125b‑5p and DEAD‑box helicase 5 (DDX5) was verified, and the expression levels of DDX5 in OC samples and SKOV3 cells were quantified using western blotting. miR‑125b‑5p was downregulated in tumor tissue samples from patients with OC. BMSCs‑Exo reduced the malignant properties of SKOV3 cells in vitro, and these effects were be advanced by miR‑125b‑5p upregulation. miR‑125b‑5p targeted and inhibited DDX5 expression. DDX5 overexpression inhibited Exo‑miR‑125b‑5p‑induced suppression of OC development. Overall, this study highlights that BMSCs‑Exo‑encapsulated miR‑125b‑5p inhibited OC progression via DDX5 downregulation, providing insight into the molecular mechanisms underlying OC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Stewart C, Ralyea C and Lockwood S: Ovarian cancer: An integrated review. Semin Oncol Nurs. 35:151–156. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Rooth C: Ovarian cancer: Risk factors, treatment and management. Br J Nurs. 22:S23–S30. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Narod S: Can advanced-stage ovarian cancer be cured? Nat Rev Clin Oncol. 13:255–261. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Crapnell K, Blaesius R, Hastings A, Lennon DP, Caplan AI and Bruder SP: Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening. Exp Cell Res. 319:1409–1418. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Mohr A and Zwacka R: The future of mesenchymal stem cell-based therapeutic approaches for cancer-from cells to ghosts. Cancer Lett. 414:239–249. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Mendt M, Rezvani K and Shpall E: Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant. 54 (Suppl 2):S789–S792. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Tan F, Li X, Wang Z, Li J, Shahzad K and Zheng J: Clinical applications of stem cell-derived exosomes. Signal Transduct Target Ther. 9:172024. View Article : Google Scholar : PubMed/NCBI

9 

Qiu L, Wang J, Chen M, Chen F and Tu W: Exosomal microRNA-146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2-mediated PI3K/Akt axis. Int J Mol Med. 46:609–620. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K and Ochiya T: Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal. 7:ra632014. View Article : Google Scholar : PubMed/NCBI

11 

Jiang S, Mo C, Guo S, Zhuang J, Huang B and Mao X: Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2. J Exp Clin Cancer Res. 38:4952019. View Article : Google Scholar : PubMed/NCBI

12 

Kalinkova L, Kajo K, Karhanek M, Wachsmannova L, Suran P, Zmetakova I and Fridrichova I: Discriminating miRNA profiles between endometrioid well- and poorly-differentiated tumours and endometrioid and serous subtypes of endometrial cancers. Int J Mol Sci. 21:60712020. View Article : Google Scholar : PubMed/NCBI

13 

de Lima AB, Silva LM, Gonçales NG, Carvalho MRS, da Silva Filho AL and da Conceição Braga L: Three-dimensional cellular arrangement in epithelial ovarian cancer cell lines TOV-21G and SKOV-3 is associated with apoptosis-related miRNA expression modulation. Cancer Microenviron. 11:85–92. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Liu J, Zhang X, Huang Y, Zhang Q, Zhou J, Zhang X and Wang X: miR-200b and miR-200c co-contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases. Oncol Lett. 17:1453–1460. 2019.PubMed/NCBI

15 

Xing Z, Ma WK and Tran EJ: The DDX5/Dbp2 subfamily of DEAD-box RNA helicases. Wiley Interdiscip Rev RNA. 10:e15192019. View Article : Google Scholar : PubMed/NCBI

16 

Li Z, Caron de Fromentel C, Kim W, Wang WH, Sun J, Yan B, Utturkar S, Lanman NA, Elzey BD, Yeo Y, et al: RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin-ferroptosis axis. Cell Death Dis. 14:7862023. View Article : Google Scholar : PubMed/NCBI

17 

Du C, Li DQ, Li N, Chen L, Li SS, Yang Y, Hou MX, Xie MJ and Zheng ZD: DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway. Sci Rep. 7:428762017. View Article : Google Scholar : PubMed/NCBI

18 

Ye X: Confluence analysis of multiple omics on platinum resistance of ovarian cancer. Eur J Gynaecol Oncol. 36:514–519. 2015.PubMed/NCBI

19 

Xu CM, Chen LX, Gao F, Zhu MF, Dai Y, Xu Y and Qian WX: MiR-431 suppresses proliferation and metastasis of lung cancer via down-regulating DDX5. Eur Rev Med Pharmacol Sci. 23:699–707. 2019.PubMed/NCBI

20 

Mallmann-Gottschalk N, Sax Y, Kimmig R, Lang S and Brandau S: EGFR-specific tyrosine kinase inhibitor modifies NK cell-mediated antitumoral activity against ovarian cancer cells. Int J Mol Sci. 20:46932019. View Article : Google Scholar : PubMed/NCBI

21 

Mahmoudian-Sani MR, Forouzanfar F, Asgharzade S and Ghorbani N: Overexpression of MiR-183/96/182 triggers retina-like fate in human bone marrow-derived mesenchymal stem cells (hBMSCs) in culture. J Ophthalmol. 2019:24543622019. View Article : Google Scholar : PubMed/NCBI

22 

Li B, Luan S, Chen J, Zhou Y, Wang T, Li Z, Fu Y, Zhai A and Bi C: The MSC-derived exosomal lncRNA H19 promotes wound healing in diabetic foot ulcers by upregulating PTEN via MicroRNA-152-3p. Mol Ther Nucleic Acids. 19:814–826. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Li W, Han Y, Zhao Z, Ji X, Wang X, Jin J, Wang Q, Guo X, Cheng Z, Lu M, et al: Oral mucosal mesenchymal stem cell-derived exosomes: A potential therapeutic target in oral premalignant lesions. Int J Oncol. 54:1567–1578. 2019.PubMed/NCBI

24 

Sun P, Fan X, Hu X, Fu X, Wei Q and Zang Y: circPCNX and pecanex promote hepatocellular carcinoma cell viability by inhibiting miR-506. Cancer Manag Res. 11:10957–10967. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y and Piao D: Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1-AKT/ERK-Snail signaling pathway. Int J Oncol. 57:183–196. 2020.PubMed/NCBI

26 

Wang S, Su X, Xu M, Xiao X, Li X, Li H, Keating A and Zhao RC: Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway. Stem Cell Res Ther. 10:1172019. View Article : Google Scholar : PubMed/NCBI

27 

Sun H, Wang H and Wang X, Aoki Y and Wang X, Yang Y, Cheng X, Wang Z and Wang X: Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells. Theranostics. 10:6928–6945. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Wu X, Zhao J, Ruan Y, Sun L, Xu C and Jiang H: Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer. Cell Death Dis. 9:11022018. View Article : Google Scholar : PubMed/NCBI

29 

Wang Z, Wang P, Cao L, Li F, Duan S, Yuan G, Xiao L, Guo L, Yin H, Xie D, et al: Long intergenic non-coding RNA 01121 promotes breast cancer cell proliferation, migration, and invasion via the miR-150-5p/HMGA2 axis. Cancer Manag Res. 11:10859–10870. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Li N, Cui T, Guo W, Wang D and Mao L: MiR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1. Onco Targets Ther. 12:3181–3196. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Liu SC, Cao YH, Chen LB, Kang R, Huang ZX and Lu XS: BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression. Cancer Biol Ther. 23:1–13. 2022. View Article : Google Scholar

32 

Xiu C, Zheng H, Jiang M, Li J, Zhou Y, Mu L and Liu W: MSCs-derived miR-150-5p-expressing exosomes promote skin wound healing by activating PI3K/AKT pathway through PTEN. Int J Stem Cells. 15:359–371. 2022. View Article : Google Scholar : PubMed/NCBI

33 

Furuta T, Miyaki S, Ishitobi H, Ogura T, Kato Y, Kamei N, Miyado K, Higashi Y and Ochi M: Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model. Stem Cells Transl Med. 5:1620–1630. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Zhang S, Ma Y, Hu X, Zheng Y and Chen X: Targeting PRMT5/Akt signalling axis prevents human lung cancer cell growth. J Cell Mol Med. 23:1333–1342. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Reza AMMT, Choi YJ, Yasuda H and Kim JH: Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Sci Rep. 6:384982016. View Article : Google Scholar : PubMed/NCBI

36 

Hua S, Quan Y, Zhan M, Liao H, Li Y and Lu L: miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1. Cancer Cell Int. 19:2032019. View Article : Google Scholar : PubMed/NCBI

37 

Wieser V, Tsibulak I, Reimer DU, Zeimet AG, Fiegl H, Hackl H and Marth C: An angiogenic tumor phenotype predicts poor prognosis in ovarian cancer. Gynecol Oncol. 170:290–299. 2023. View Article : Google Scholar : PubMed/NCBI

38 

de Araujo Farias V, O'Valle F, Serrano-Saenz S, Anderson P, Andrés E, López-Peñalver J, Tovar I, Nieto A, Santos A, Martín F, et al: Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci. Mol Cancer. 17:1222018. View Article : Google Scholar : PubMed/NCBI

39 

Xu H, Zhao G, Zhang Y, Jiang H, Wang W, Zhao D, Hong J, Yu H and Qi L: Mesenchymal stem cell-derived exosomal microRNA-133b suppresses glioma progression via Wnt/β-catenin signaling pathway by targeting EZH2. Stem Cell Res Ther. 10:3812019. View Article : Google Scholar : PubMed/NCBI

40 

Shang S, Wang J, Chen S, Tian R, Zeng H, Wang L, Xia M, Zhu H and Zuo C: Exosomal miRNA-1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer. Cancer Med. 8:7728–7740. 2019. View Article : Google Scholar : PubMed/NCBI

41 

He Z, Li W, Zheng T, Liu D and Zhao S: Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression. J Exp Clin Cancer Res. 39:1402020. View Article : Google Scholar : PubMed/NCBI

42 

Shi H, Li K, Feng J, Liu G, Feng Y and Zhang X: LncRNA-DANCR interferes with miR-125b-5p/HK2 axis to desensitize colon cancer cells to cisplatin vis activating anaerobic glycolysis. Front Oncol. 10:10342020. View Article : Google Scholar : PubMed/NCBI

43 

Liu S, Chen Q and Wang Y: MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway. Hum Cell. 33:185–194. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Li Y, Wang Y, Fan H, Zhang Z and Li N: miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522. Biochem Biophys Res Commun. 504:277–282. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Yang D, Zhan M, Chen T, Chen W, Zhang Y, Xu S, Yan J, Huang Q and Wang J: miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer. Sci Rep. 7:431092017. View Article : Google Scholar : PubMed/NCBI

46 

Mei LL, Wang WJ, Qiu YT, Xie XF, Bai J and Shi ZZ: miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma. PLoS One. 12:e01856362017. View Article : Google Scholar : PubMed/NCBI

47 

Zhang M, Weng W, Zhang Q, Wu Y, Ni S, Tan C, Xu M, Sun H, Liu C, Wei P and Du X: The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5. J Hematol Oncol. 11:1132018. View Article : Google Scholar : PubMed/NCBI

48 

Xing Z, Russon MP, Utturkar SM and Tran EJ: The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer. J Biol Chem. 295:8988–8998. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Liu C, Wang L, Jiang Q, Zhang J, Zhu L, Lin L, Jiang H, Lin D, Xiao Y, Fang W and Guo S: Hepatoma-derived growth factor and DDX5 promote carcinogenesis and progression of endometrial cancer by activating β-catenin. Front Oncol. 9:2112019. View Article : Google Scholar : PubMed/NCBI

50 

Wang Z, Luo Z, Zhou L, Li X, Jiang T and Fu E: DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating β-catenin signaling pathway. Cancer Sci. 106:1303–1312. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang W, Zheng D and Gao Y: Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation. Oncol Lett 29: 255, 2025.
APA
Wang, Y., Wang, W., Zheng, D., & Gao, Y. (2025). Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation. Oncology Letters, 29, 255. https://doi.org/10.3892/ol.2025.15001
MLA
Wang, Y., Wang, W., Zheng, D., Gao, Y."Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation". Oncology Letters 29.5 (2025): 255.
Chicago
Wang, Y., Wang, W., Zheng, D., Gao, Y."Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation". Oncology Letters 29, no. 5 (2025): 255. https://doi.org/10.3892/ol.2025.15001
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang W, Zheng D and Gao Y: Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation. Oncol Lett 29: 255, 2025.
APA
Wang, Y., Wang, W., Zheng, D., & Gao, Y. (2025). Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation. Oncology Letters, 29, 255. https://doi.org/10.3892/ol.2025.15001
MLA
Wang, Y., Wang, W., Zheng, D., Gao, Y."Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation". Oncology Letters 29.5 (2025): 255.
Chicago
Wang, Y., Wang, W., Zheng, D., Gao, Y."Bone mesenchymal stem cell‑derived exosome‑encapsulated microRNA‑125b‑5p inhibits ovarian cancer progression via DDX5 downregulation". Oncology Letters 29, no. 5 (2025): 255. https://doi.org/10.3892/ol.2025.15001
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team