Giant liposarcoma of the esophagus is an exceedingly rare esophageal tumor with complex treatment options. This study investigated the treatment modalities and reported on the clinical outcomes of two cases involving giant, well‑differentiated liposarcoma of the esophagus, providing a reference for the management of similar cases. Both tumors measured >20 cm in length and had diameters exceeding 4 cm; one case exhibited a lobulated appearance with visibly expanded blood vessels on its surface. Following discussions within a multidisciplinary team, under general anesthesia with tracheal intubation, the endoscopy team conducted endoscopic submucosal dissection, collaborating with the thoracic surgery team to manage potential bleeding risks. Both patients successfully underwent endoscopic tumor removal with postoperative pathology confirming the presence of well‑differentiated liposarcoma and no observed complications. For patients with giant and complex well‑differentiated liposarcomas, endoscopic dissection in conjunction with multidisciplinary collaboration represents a safe and effective treatment option, ensuring complete tumor removal while minimizing surgical trauma and enhancing patient prognosis.

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