Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma

  • Authors:
    • Urs D.A. Müller-Richter
    • Albert Dowejko
    • Oliver Driemel
    • Tobias Reuther
    • Torsten E. Reichert
    • Alexander C. Kübler
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/ol_00000033
  • Pages: 181-185
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Abstract

MAGE-A antigens are a subgroup of cancer/testis antigens that are exclusively expressed in malignant cells. Only scarce information on the function of MAGE-A antigens is available. There is some evidence that they may influence the response to chemotherapeutic drugs. This study aimed to evaluate the impact of the MAGE-A antigen subgroups MAGE-A2, -A3, -A4 and -A6 on oral squamous cell carcinoma cell lines treated with docetaxel and paclitaxel. Five oral squamous cell carcinoma cell lines were characterized for their quantitative expression of MAGE-A2, -A3, -A4 and -A6. The cell lines were treated with concentrations ranging from 0.025 to 0.8 µM of docetaxel and paclitaxel. The amount of viable cells after 24 and 48 h was measured. The measurements were statistically correlated with MAGE-A expression. All cell lines responded to docetaxel and paclitaxel. One cell line showed a statistically significant weaker response to the taxane treatment. This cell line was the only one that expressed MAGE-A4. MAGE-A4 has a statistically significant impact on the tumour response to docetaxel and paclitaxel in oral squamous cell carcinoma. This may influence treatment options and the course of the disease. Therefore, patients should be evaluated for MAGE-A4 expression before treatment with taxanes.
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January-February 2010
Volume 1 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Müller-Richter UD, Dowejko A, Driemel O, Reuther T, Reichert TE and Kübler AC: Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma . Oncol Lett 1: 181-185, 2010.
APA
Müller-Richter, U.D., Dowejko, A., Driemel, O., Reuther, T., Reichert, T.E., & Kübler, A.C. (2010). Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma . Oncology Letters, 1, 181-185. https://doi.org/10.3892/ol_00000033
MLA
Müller-Richter, U. D., Dowejko, A., Driemel, O., Reuther, T., Reichert, T. E., Kübler, A. C."Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma ". Oncology Letters 1.1 (2010): 181-185.
Chicago
Müller-Richter, U. D., Dowejko, A., Driemel, O., Reuther, T., Reichert, T. E., Kübler, A. C."Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma ". Oncology Letters 1, no. 1 (2010): 181-185. https://doi.org/10.3892/ol_00000033