BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome

  • Authors:
    • Walid Al-Achkar
    • Abdulsamad Wafa
    • Suher Almedani
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  • Published online on: May 1, 2010     https://doi.org/10.3892/ol_00000078
  • Pages: 445-447
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Abstract

The well-known typical fusion gene BCR/ABL is observed in connection with a complex translocation event in 5-8% of cases of chronic myeloid leukemia (CML). The present study described an exceptional CML case with complex chromosomal aberrations not previously observed. Aberrations included a translocated BCR to the derivative chromosome 2 [der(2)] that also involved a four-chromosome translocation, implying chromosomal regions 1p32 and 2q21, besides 9q34 and 22q11.2, which were characterized by molecular cytogenetics.
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May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al-Achkar W, Wafa A and Almedani S: BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome . Oncol Lett 1: 445-447, 2010.
APA
Al-Achkar, W., Wafa, A., & Almedani, S. (2010). BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome . Oncology Letters, 1, 445-447. https://doi.org/10.3892/ol_00000078
MLA
Al-Achkar, W., Wafa, A., Almedani, S."BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome ". Oncology Letters 1.3 (2010): 445-447.
Chicago
Al-Achkar, W., Wafa, A., Almedani, S."BCR translocation to derivative chromosome 2: A new case of chronic myeloid leukemia with a complex variant translocation and Philadelphia chromosome ". Oncology Letters 1, no. 3 (2010): 445-447. https://doi.org/10.3892/ol_00000078