MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma

  • Authors:
    • Koshiro Harata
    • Hideyuki Ishiguro
    • Yoshiyuki Kuwabara
    • Masahiro Kimura
    • Akira Mitsui
    • Ryo Ogawa
    • Takeyasu Katada
    • Tatsuya Tanaka
    • Midori Shiozaki
    • Yoshitaka Fujii
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/ol_00000120
  • Pages: 685-689
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a common malignancy and one of the more difficult diseases to diagnose in Japan due to its poor prognosis. MicroRNAs are small non-coding RNAs of 21-23 nucleotides that regulate gene expression. MicroRNA-34b (miR-34b) has been reported to be overexpressed in various types of cancer. However, its role in ESCC has yet to be extensively studied. The present study investigated the expression of miR-34b in 88 ESCC patients. The miR-34b expression in ESCC was significantly higher than that in the corresponding normal esophageal mucosa. It was more highly expressed in tumors with more advanced stages. However, its expression did not correlate with the p53 status. Transfection of anti-miR-34b to the ESCC cells suppressed cell growth in vitro. These results suggest an oncogenic role of miR in ESCC.
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July-August 2010
Volume 1 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Harata K, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Ogawa R, Katada T, Tanaka T, Shiozaki M, Fujii Y, Fujii Y, et al: MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma . Oncol Lett 1: 685-689, 2010.
APA
Harata, K., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Ogawa, R. ... Fujii, Y. (2010). MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma . Oncology Letters, 1, 685-689. https://doi.org/10.3892/ol_00000120
MLA
Harata, K., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Ogawa, R., Katada, T., Tanaka, T., Shiozaki, M., Fujii, Y."MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma ". Oncology Letters 1.4 (2010): 685-689.
Chicago
Harata, K., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Ogawa, R., Katada, T., Tanaka, T., Shiozaki, M., Fujii, Y."MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma ". Oncology Letters 1, no. 4 (2010): 685-689. https://doi.org/10.3892/ol_00000120