A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17)

  • Authors:
    • Walid Al Achkar
    • Abdulsamad Wafa
    • Hasmik Mkrtchyan
    • Faten Moassass
    • Thomas Liehr
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  • Published online on: September 1, 2010     https://doi.org/10.3892/ol_00000138
  • Pages: 793-795
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Abstract

The reciprocal translocation t(9;22)(q34;q11), leading to the formation of two fusion genes, BCR/ABL and ABL/BCR, is found in 90-95% of cases with chronic myeloid leukemia (CML). ABL-BCR expression does not correlate with prognosis, as assessed by cytogenetic response, since the ABL/BCR gene is expressed in only a proportion of CML patients. This study examined an exceptional BCR/ABL-positive CML case with inversion in 9q22q34 leading to the absence of ABL/BCR. Moreover, an unbalanced translocation between chromosomes 10 and 17 which caused deletion of the TP53 gene was identified. The TP53 gene plays a potential role in CML progression, and loss of TP53 may be regarded as a poor prognostic factor.
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September-October 2010
Volume 1 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al Achkar W, Wafa A, Mkrtchyan H, Moassass F and Liehr T: A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17) . Oncol Lett 1: 793-795, 2010.
APA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., & Liehr, T. (2010). A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17) . Oncology Letters, 1, 793-795. https://doi.org/10.3892/ol_00000138
MLA
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17) ". Oncology Letters 1.5 (2010): 793-795.
Chicago
Al Achkar, W., Wafa, A., Mkrtchyan, H., Moassass, F., Liehr, T."A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17) ". Oncology Letters 1, no. 5 (2010): 793-795. https://doi.org/10.3892/ol_00000138