Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer

  • Authors:
    • Yoshimasa Inoue
    • Hozumi Matsumoto
    • Shunsuke Yamada
    • Kenji Kawai
    • Hiroshi Suemizu
    • Masatoshi Gika
    • Iwao Takanami
    • Masayuki Iwazaki
    • Masato Nakamura
  • View Affiliations

  • Published online on: September 1, 2010     https://doi.org/10.3892/ol_00000147
  • Pages: 837-840
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Abstract

Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro cisplatin (CDDP) sensitivity was investigated using the collagen gel-droplet embedded culture drug sensitivity test, and the ATP7A mRNA expression levels were assessed by real-time polymerase chain reaction in surgically resected specimens of NSCLC. The relationship between the ATP7A expression levels and the in vitro CDDP sensitivity was then evaluated. The ATP7A mRNA expression levels in the CDDP-resistant tumors were significantly higher than those in the CDDP-sensitive tumors (p=0.0167, Mann-Whitney U test). In conclusion, the results suggest that evaluation of ATP7A expression is useful as a marker for cisplatin chemoresistance.
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September-October 2010
Volume 1 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Inoue Y, Matsumoto H, Yamada S, Kawai K, Suemizu H, Gika M, Takanami I, Iwazaki M and Nakamura M: Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncol Lett 1: 837-840, 2010.
APA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M. ... Nakamura, M. (2010). Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncology Letters, 1, 837-840. https://doi.org/10.3892/ol_00000147
MLA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1.5 (2010): 837-840.
Chicago
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1, no. 5 (2010): 837-840. https://doi.org/10.3892/ol_00000147