ALLELIC LOSS AT CHROMOSOME 8P IN HUMAN BREAST-CANCER
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- Published online on: March 1, 1994 https://doi.org/10.3892/or.1.2.393
- Pages: 393-395
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Abstract
Loss of heterozygosity (LOH) at loci from the short arm of chromosome 8 has been shown to occur in several types of carcinomas. The consensus deletion region has been recently mapped at 8p21-p22, distal to D8S283 and NEFL loci, and proximal to LPL and D8S265 loci. We report LOH at D8S133, a marker located in this consensus region, in a panel of breast tumor samples. LOH at this locus was observed in about 20% of the tumors.