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EXPRESSION OF THE CARCINOMA-ASSOCIATED LE(A)-LE(X) OLIGOSACCHARIDE IN VERTEBRATE ENDODERM AND ITS FETAL DERIVATIVES

  • Authors:
    • PL STRANAHAN
    • J LAROE
    • D REDDY
    • I RAHIM
    • M OVERLAND
    • DE PETTIJOHN

  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.607
  • Pages: 607-611
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Abstract

The extended Le(a)-Le(x) oligosaccharide, expressed as a cell surface antigen by human squamous lung carcinomas marks cancer cells of tumors having poor prognosis. In order to see if the extended Le(a)-Le(x) also has a precisely controlled pattern of expression during embryogenesis, a survey of representative vertebrate embryos and fetuses in various stages was undertaken. Embryonic and fetal cells which express the epitope are derived from embryonic endoderm. No. epitope expression was demonstrated in tissues of ectodermal or mesodermal origin. Vertebrate conservation of this endodermal cell surface carbohydrate suggests function necessary for normal growth and development with inappropriate re-expression during carcinogenesis.

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May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
STRANAHAN P, LAROE J, REDDY D, RAHIM I, OVERLAND M and PETTIJOHN D: EXPRESSION OF THE CARCINOMA-ASSOCIATED LE(A)-LE(X) OLIGOSACCHARIDE IN VERTEBRATE ENDODERM AND ITS FETAL DERIVATIVES. Oncol Rep 1: 607-611, 1994.
APA
STRANAHAN, P., LAROE, J., REDDY, D., RAHIM, I., OVERLAND, M., & PETTIJOHN, D. (1994). EXPRESSION OF THE CARCINOMA-ASSOCIATED LE(A)-LE(X) OLIGOSACCHARIDE IN VERTEBRATE ENDODERM AND ITS FETAL DERIVATIVES. Oncology Reports, 1, 607-611. https://doi.org/10.3892/or.1.3.607
MLA
STRANAHAN, P., LAROE, J., REDDY, D., RAHIM, I., OVERLAND, M., PETTIJOHN, D."EXPRESSION OF THE CARCINOMA-ASSOCIATED LE(A)-LE(X) OLIGOSACCHARIDE IN VERTEBRATE ENDODERM AND ITS FETAL DERIVATIVES". Oncology Reports 1.3 (1994): 607-611.
Chicago
STRANAHAN, P., LAROE, J., REDDY, D., RAHIM, I., OVERLAND, M., PETTIJOHN, D."EXPRESSION OF THE CARCINOMA-ASSOCIATED LE(A)-LE(X) OLIGOSACCHARIDE IN VERTEBRATE ENDODERM AND ITS FETAL DERIVATIVES". Oncology Reports 1, no. 3 (1994): 607-611. https://doi.org/10.3892/or.1.3.607