INDUCTION OF BREAST NEOPLASIA AND LUNG GRANULOMAS IN MICE BY AN ANTIFUNGAL DRUG (GRISEOFULVIN)
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- Published online on: November 1, 1994 https://doi.org/10.3892/or.1.6.1079
- Pages: 1079-1081
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Abstract
Infiltrating duct carcinomas were induced in the mammary glands of 7 out of 60 experimental female mice force-fed with the antifungal drug griseofulvin, at a daily dose lever of 0.3 mg/30g body weight, for 12 months. The first mammary gland tumor appeared 8 months after the initiation of feeding. Other pathological changes such as bronchocentric granulomas appeared in some male and female treated animals (16.5%).