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Detection of disseminated cancer cells in rib marrow of patients with esophageal cancer

  • Authors:
    • Tsuyoshi Noguchi
    • Tomotaka Shibata
    • Shoichi Fumoto
    • Tetsuro Sato
    • Yuzo Uchida
    • Tsutomu Daa
    • Shigeo Yokoyama
    • Helmut E. Gabbert
    • Wolfram Mueller
    • Shinsuke Takeno

  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/or.10.3.623
  • Pages: 623-627
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Abstract

In the present study, micrometastasis in the rib marrow of 24 patients with esophageal cancer was examined using RT-PCR. RT-PCR was done using primers corresponding to cytokeratin 18 (CK18), squamous cell carcinoma antigen (SCC), and carcinoembryonic antigen (CEA). In 18 cases, CK18 was also detected in the rib marrow. Only one patient exhibited CEA amplification in the rib marrow. No cases demonstrated SCC amplification as a marker of micrometastasis in the rib marrow. The information from micrometastasis detected in the rib marrow using RT-PCR is useful in deciding whether or not adjuvant therapy is necessary after surgery. However, combined analysis using plural markers should be required since sensitivity or specificity of each marker may vary. Further follow-up of the patients is necessary to clarify the clinical impact of micrometastasis in rib marrow.

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May-June 2003
Volume 10 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Noguchi T, Shibata T, Fumoto S, Sato T, Uchida Y, Daa T, Yokoyama S, Gabbert HE, Mueller W, Takeno S, Takeno S, et al: Detection of disseminated cancer cells in rib marrow of patients with esophageal cancer. Oncol Rep 10: 623-627, 2003.
APA
Noguchi, T., Shibata, T., Fumoto, S., Sato, T., Uchida, Y., Daa, T. ... Takeno, S. (2003). Detection of disseminated cancer cells in rib marrow of patients with esophageal cancer. Oncology Reports, 10, 623-627. https://doi.org/10.3892/or.10.3.623
MLA
Noguchi, T., Shibata, T., Fumoto, S., Sato, T., Uchida, Y., Daa, T., Yokoyama, S., Gabbert, H. E., Mueller, W., Takeno, S."Detection of disseminated cancer cells in rib marrow of patients with esophageal cancer". Oncology Reports 10.3 (2003): 623-627.
Chicago
Noguchi, T., Shibata, T., Fumoto, S., Sato, T., Uchida, Y., Daa, T., Yokoyama, S., Gabbert, H. E., Mueller, W., Takeno, S."Detection of disseminated cancer cells in rib marrow of patients with esophageal cancer". Oncology Reports 10, no. 3 (2003): 623-627. https://doi.org/10.3892/or.10.3.623