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Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer

  • Authors:
    • Kun-Tu Yeh
    • Jan-Gowth Chang
    • Ting-Hsu Lin
    • Yu-Fen Wang
    • Ni Tien
    • Jan-Yi Chang
    • Jui-Chang Chen
    • Mu-Chin Shih

  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/or.10.3.659
  • Pages: 659-663
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Altogether, over 50% of the samples showed the CpG-island methylation modification in at least one of the three tumor suppressor genes, indicating that the frequent inactivation of these genes may be an important step during oral cancer development, and the methylation inactivation of P15 or P16 may occur at pre-cancerous stage.

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May-June 2003
Volume 10 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Yeh K, Chang J, Lin T, Wang Y, Tien N, Chang J, Chen J and Shih M: Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. Oncol Rep 10: 659-663, 2003.
APA
Yeh, K., Chang, J., Lin, T., Wang, Y., Tien, N., Chang, J. ... Shih, M. (2003). Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer. Oncology Reports, 10, 659-663. https://doi.org/10.3892/or.10.3.659
MLA
Yeh, K., Chang, J., Lin, T., Wang, Y., Tien, N., Chang, J., Chen, J., Shih, M."Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer". Oncology Reports 10.3 (2003): 659-663.
Chicago
Yeh, K., Chang, J., Lin, T., Wang, Y., Tien, N., Chang, J., Chen, J., Shih, M."Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer". Oncology Reports 10, no. 3 (2003): 659-663. https://doi.org/10.3892/or.10.3.659