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BRCA2 germline mutations in primary cancer of the fallopian tube

  • Authors:
    • Sara Casarsa
    • Fabio Puglisi
    • Francesco Baudi
    • Loredana De Paola
    • Salvatore Venuta
    • Andrea Piga
    • Carla Di Loreto
    • Diego Marchesoni
    • Angela Valentina D'Elia
    • Giuseppe Damante

  • View Affiliations

  • Published online on: August 1, 2004     https://doi.org/10.3892/or.12.2.313
  • Pages: 313-316
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Abstract

Germline mutations of BRCA1 and BRCA2 genes confer susceptibility to breast and ovarian cancer. It has been recently reported that BRCA1/2 mutations may also predispose to fallopian tube cancer. We report the presence of germline BRCA2 gene mutations in three out of four subjects with fallopian tube cancer diagnosed in a two-year time span at our clinic. The mothers of two of these women suffered from breast or ovarian carcinoma. These results suggest on one hand that in patients with a history suggestive for a heredofamilial breast/ovarian cancer syndrome fallopian tube carcinoma is associated with high risk of BRCA2 mutation, and on the other hand that in patients/individuals with germline BRCA2 gene mutations in whom a prophylactic oophorectomy is performed, removal of fallopian tubes may be considered.

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Journal Cover

August 2004
Volume 12 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Casarsa S, Puglisi F, Baudi F, De Paola L, Venuta S, Piga A, Di Loreto C, Marchesoni D, D'Elia AV, Damante G, Damante G, et al: BRCA2 germline mutations in primary cancer of the fallopian tube. Oncol Rep 12: 313-316, 2004.
APA
Casarsa, S., Puglisi, F., Baudi, F., De Paola, L., Venuta, S., Piga, A. ... Damante, G. (2004). BRCA2 germline mutations in primary cancer of the fallopian tube. Oncology Reports, 12, 313-316. https://doi.org/10.3892/or.12.2.313
MLA
Casarsa, S., Puglisi, F., Baudi, F., De Paola, L., Venuta, S., Piga, A., Di Loreto, C., Marchesoni, D., D'Elia, A. V., Damante, G."BRCA2 germline mutations in primary cancer of the fallopian tube". Oncology Reports 12.2 (2004): 313-316.
Chicago
Casarsa, S., Puglisi, F., Baudi, F., De Paola, L., Venuta, S., Piga, A., Di Loreto, C., Marchesoni, D., D'Elia, A. V., Damante, G."BRCA2 germline mutations in primary cancer of the fallopian tube". Oncology Reports 12, no. 2 (2004): 313-316. https://doi.org/10.3892/or.12.2.313