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Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma

  • Authors:
    • Pilar Gonzalez-Gomez
    • M. J. Bello
    • M. M. Inda
    • M. E. Alonso
    • Dolores Arjona
    • Cinthia Amiñoso
    • Isabel Lopez-Marin
    • J. M. De Campos
    • J. L. Sarasa
    • J. S. Castresana
    • J. A. Rey

  • View Affiliations

  • Published online on: September 1, 2004     https://doi.org/10.3892/or.12.3.663
  • Pages: 663-666
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Abstract

Aberrant methylation of promoter CpG islands in human genes is an alternative genetic inactivation mechanism that contributes to the development of human tumors. Nevertheless, few studies have analyzed methylation in medulloblastomas. We determined the frequency of aberrant CpG island methylation for Caspase 8 (CASP8) in a group of 24 medulloblastomas arising in 8 adult and 16 pediatric patients. Complete methylation of CASP8 was found in 15 tumors (62%) and one case displayed hemimethylation. Three samples amplified neither of the two primer sets for methylated or unmethylated alleles, suggesting that genomic deletion occurred in the 5' flanking region of CASP8. Our findings suggest that methylation commonly contributes to CASP8 silencing in medulloblastomas and that homozygous deletion or severe sequence changes involving the promoter region may be another mechanism leading to CASP8 inactivation in this neoplasm.

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September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
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Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Inda MM, Alonso ME, Arjona D, Amiñoso C, Lopez-Marin I, De Campos JM, Sarasa JL, Castresana JS, Castresana JS, et al: Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma. Oncol Rep 12: 663-666, 2004.
APA
Gonzalez-Gomez, P., Bello, M.J., Inda, M.M., Alonso, M.E., Arjona, D., Amiñoso, C. ... Rey, J.A. (2004). Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma. Oncology Reports, 12, 663-666. https://doi.org/10.3892/or.12.3.663
MLA
Gonzalez-Gomez, P., Bello, M. J., Inda, M. M., Alonso, M. E., Arjona, D., Amiñoso, C., Lopez-Marin, I., De Campos, J. M., Sarasa, J. L., Castresana, J. S., Rey, J. A."Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma". Oncology Reports 12.3 (2004): 663-666.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Inda, M. M., Alonso, M. E., Arjona, D., Amiñoso, C., Lopez-Marin, I., De Campos, J. M., Sarasa, J. L., Castresana, J. S., Rey, J. A."Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma". Oncology Reports 12, no. 3 (2004): 663-666. https://doi.org/10.3892/or.12.3.663