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Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat

  • Authors:
    • Keiko Matono
    • Yutaka Ogata
    • Hideaki Tsuda
    • Yasumi Araki
    • Kazuo Shirouzu

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  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.389
  • Pages: 389-395
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Abstract

We have investigated the efficacy and mechanisms of antineoplaston AS2-1 against post-operative lung metastasis following removal of implanted human colon cancer in nude rat. The influence of AS2-1 on in vitro KM12SM human colon carcinoma cell activities (growth, cell cycle, and apoptosis) was evaluated. AS2-1 was administered perorally after removal of the implanted KM12SM cecal cancer in nude rat. AS2-1 inhibited KM12SM cell proliferation through G1 cell arrest and, at a higher concentration, induction of apoptosis. AS2-1 showed significant reduction in lung metastasis at 5 weeks after cecal removal. The survival rate in the AS2-1 group was significantly higher than that in the control. TUNEL staining on the lung metastatic tumors revealed that the apoptosis index (AI) in the AS2-1 group was significantly higher. Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Matono K, Ogata Y, Tsuda H, Araki Y and Shirouzu K: Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncol Rep 13: 389-395, 2005.
APA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., & Shirouzu, K. (2005). Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncology Reports, 13, 389-395. https://doi.org/10.3892/or.13.3.389
MLA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13.3 (2005): 389-395.
Chicago
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13, no. 3 (2005): 389-395. https://doi.org/10.3892/or.13.3.389