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Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation

  • Authors:
    • Pal I. Bauer
    • Eva Kirsten
    • Ernest Kun

  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/or.13.3.465
  • Pages: 465-468
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Abstract

The tumoricidal mechanism of methyl-3,5-diiodo-4-(4'-methoxypropoxy)benzoate (DIME), or DIPE, has been analyzed beyond its first recognized cellular site, which is the inhibition of tubulin polymerization. DIME (or DIPE) pretreatment of Eras cells for 3 days abolished ceramide basic fibroblast growth factor (bFGF)-induced glycolysis, coinciding with a block produced by the phosphoprotein dephosphorylation of cdc 25 by protein phosphatase 2A (PP2A). Protein dephosphorylation is directly activated by DIME (or DIPE), and enzyme activities that are dependent on P-proteins are significantly down-regulated (e.g. Topo I and II, MAP-kinase, and cdc-cyclin kinase). Purified PP2A is one target of activation by DIME (or DIPE), and an alkaline phosphatase isoenzyme is also induced by the drug. It is proposed that the pleiotropic effects of DIME (or DIPE) on cancer cells involve the activation of protein dephosphorylations, as well as inhibition of tubulin polymerization.

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March 2005
Volume 13 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Bauer PI, Kirsten E and Kun E: Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncol Rep 13: 465-468, 2005.
APA
Bauer, P.I., Kirsten, E., & Kun, E. (2005). Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation. Oncology Reports, 13, 465-468. https://doi.org/10.3892/or.13.3.465
MLA
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13.3 (2005): 465-468.
Chicago
Bauer, P. I., Kirsten, E., Kun, E."Mechanisms of antitumor action of methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate: Drug-induced protein dephosphorylations and inhibition of the permissive action of ceramide on growth factor induced cell proliferation". Oncology Reports 13, no. 3 (2005): 465-468. https://doi.org/10.3892/or.13.3.465