search button

Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair

  • Authors:
    • G. P. Raaphorst
    • L. F. Li
    • D. P. Yang
    • J.-M. Leblanc

  • View Affiliations

  • Published online on: July 1, 2005     https://doi.org/10.3892/or.14.1.281
  • Pages: 281-285
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The effect of mild hyperthermia on cisplatin sensitization was examined in two cell line pairs, CHO parental AA8 and irsISF, an XRCC3 mutant (deficient in homologous recombination repair), and mouse parental MEF and knockout Ku80 mutants (deficient in non-homologous endjoining repair). The results showed that mild hyperthermia 40, 41 and 42°C given concurrently with cisplatin treatment caused significant sensitization. The degree of sensitization was comparable for the parental and mutant lines, indicating that these repair pathways were likely not involved in cisplatin thermal sensitization. The shorter concurrent treatments cause a larger sensitization than the longer treatments. The reasons for this are not clear, but thermotolerance may be a factor.

Related Articles

Journal Cover

July 2005
Volume 14 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Raaphorst GP, Li LF, Yang DP and Leblanc J: Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair . Oncol Rep 14: 281-285, 2005.
APA
Raaphorst, G.P., Li, L.F., Yang, D.P., & Leblanc, J. (2005). Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair . Oncology Reports, 14, 281-285. https://doi.org/10.3892/or.14.1.281
MLA
Raaphorst, G. P., Li, L. F., Yang, D. P., Leblanc, J."Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair ". Oncology Reports 14.1 (2005): 281-285.
Chicago
Raaphorst, G. P., Li, L. F., Yang, D. P., Leblanc, J."Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair ". Oncology Reports 14, no. 1 (2005): 281-285. https://doi.org/10.3892/or.14.1.281