Aberrant expression of β-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: Relation to tumor proliferation and metastasis

  • Authors:
    • Chuan-Xiang Zhou
    • Yan Gao
  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/or.16.3.505
  • Pages: 505-511
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aims of this study were to investigate the expression levels of β-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas (SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether β-catenin expression was aberrant in SACC and whether Pin1 was involved in aberrant β-catenin and cyclin D1 expression. The expression of Pin1, β-catenin and cyclin D1 were examined in the specimens of 65 patients with SACC by immunohistochemistry, protein and mRNA expressions were detected by western blotting and RT-PCR in four SACC cell lines. Pin1 was overexpressed in 51 cases of SACC (78%), and high levels of Pin1 expression correlated with cyclin D1 positive expression (p=0.02). Fourteen (22%) cases showed positive immunoreactivity for β-catenin protein in the nuclear/cytoplasmic fraction in tumor tissues, which was defined as cytoplasm/nucleus staining, among which quite evident nuclear expression of β-catenin was detected in six cases (9%), while cyclin D1 positive expression was detected in 41 cases of SACC (63%). Reduced membranous expression of β-catenin was detected in the cases with metastasis (11/14). Theses results suggest that Pin1 and Wnt signalling pathway are activated in SACC and may play a pivotal role in SACC carcinogenesis and metastasis.

Related Articles

Journal Cover

September 2006
Volume 16 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C and Gao Y: Aberrant expression of β-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: Relation to tumor proliferation and metastasis. Oncol Rep 16: 505-511, 2006.
APA
Zhou, C., & Gao, Y. (2006). Aberrant expression of β-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: Relation to tumor proliferation and metastasis. Oncology Reports, 16, 505-511. https://doi.org/10.3892/or.16.3.505
MLA
Zhou, C., Gao, Y."Aberrant expression of β-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: Relation to tumor proliferation and metastasis". Oncology Reports 16.3 (2006): 505-511.
Chicago
Zhou, C., Gao, Y."Aberrant expression of β-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: Relation to tumor proliferation and metastasis". Oncology Reports 16, no. 3 (2006): 505-511. https://doi.org/10.3892/or.16.3.505