Increased BRCA1 protein in mammary tumours of rats fed marine ω-3 fatty acids
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- Published online on: April 1, 2007 https://doi.org/10.3892/or.17.4.713
- Pages: 713-719
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Abstract
Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major ω-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.