Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10
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- Published online on: April 1, 2007 https://doi.org/10.3892/or.17.4.721
- Pages: 721-729
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Abstract
Pyloric-gland type adenoma of the gallbladder is formed by proliferation of glands resembling pyloric glands, morphologically. No previous report has described the cellular phenotype and differentiation of pyloric-gland type adenoma of the gallbladder, using CD10 as a marker of proper biliary phenotype. Immunostainings were performed for mucin markers such as MUC5AC, human gastric mucin (HGM) for gastric foveolar type epithelium, MUC6, M-GGMC-1 for pyloric-gland type and MUC2 for intestinal goblet-cell type, and for CD10 as a proper biliary type marker on 58 pyloric-gland type adenomas of the gallbladder, as well as for p53, Ki-67 and CDX2. The percentage (X) of reactive cells in relation to the total number of tumor cells was estimated semi-quantitatively, and divided into four categories: X=0% (negative), 0%
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April 2007
Volume 17 Issue 4
Print ISSN: 1021-335X
Online ISSN:1791-2431
