Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma

  • Authors:
    • Eiji Noda
    • Kiyoshi Maeda
    • Toru Inoue
    • Tamahiro Nishihara
    • Yukio Nishiguchi
    • Masaichi Ohira
    • Kosei Hirakawa
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/or.17.6.1327
  • Pages: 1327-1331
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Abstract

Vascular endothelial growth factor-C (VEGF-C) is considered to be a specific factor promoting lymphangiogenesis. There have been reports of a positive correlation between local recurrence of rectal carcinoma and lymphatic invasion by the tumor. The aim of this study was to determine the clinical significance of VEGF-C expression for identifying lymphangiogenesis as a predictor of the local recurrence of rectal carcinoma. One hundred surgical specimens of rectal carcinoma from patients with (n=26) or without (n=74) local recurrence were studied. VEGF-C protein expression was assessed immunohistochemically. The correlations between VEGF-C expression, various clinicopathologic factors, the microscopic lymphatic vessel density (MLVD), and lymphatic invasion were studied. The MLVD (determined by immunohistostaining for D2-40) was significantly higher in VEGF-C positive tumors than VEGF-C negative tumors. VEGF-C positivity was only correlated with lymphatic involvement. Moreover, multivariate analysis showed that VEGF-C protein expression was an independent risk factor for the local recurrence of rectal carcinoma, and patients with VEGF-C positive tumors had a significantly worse prognosis than those with VEGF-C negative tumors. Expression of VEGF-C may be a good predictor of the local recurrence of rectal carcinoma and may also be a useful prognostic indicator.

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June 2007
Volume 17 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Noda E, Maeda K, Inoue T, Nishihara T, Nishiguchi Y, Ohira M and Hirakawa K: Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma. Oncol Rep 17: 1327-1331, 2007.
APA
Noda, E., Maeda, K., Inoue, T., Nishihara, T., Nishiguchi, Y., Ohira, M., & Hirakawa, K. (2007). Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma. Oncology Reports, 17, 1327-1331. https://doi.org/10.3892/or.17.6.1327
MLA
Noda, E., Maeda, K., Inoue, T., Nishihara, T., Nishiguchi, Y., Ohira, M., Hirakawa, K."Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma". Oncology Reports 17.6 (2007): 1327-1331.
Chicago
Noda, E., Maeda, K., Inoue, T., Nishihara, T., Nishiguchi, Y., Ohira, M., Hirakawa, K."Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma". Oncology Reports 17, no. 6 (2007): 1327-1331. https://doi.org/10.3892/or.17.6.1327