NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC-CANCER - PRELIMINARY-RESULTS OF A PHASE-II TRIAL WITH A MODIFIED FAMTX COMBINATION

FACCHINI,G; TORTORIELLO,A; CAPONIGRO,F; BENASSAI,G; BUCCI,L; GESUE,G; SARNELLA,G; GIGLIO,D; PERSICO,G; IAFFAIOLI,RV

doi:10.3892/or.2.5.727

NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC-CANCER - PRELIMINARY-RESULTS OF A PHASE-II TRIAL WITH A MODIFIED FAMTX COMBINATION

Authors:
- G FACCHINI
- A TORTORIELLO
- F CAPONIGRO
- G BENASSAI
- L BUCCI
- G GESUE
- G SARNELLA
- D GIGLIO
- G PERSICO
- RV IAFFAIOLI
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Affiliations: UNIV NAPLES,MED CLIN 1,I-80131 NAPLES,ITALY. UNIV CAGLIARI,IST MED INTERNA,I-09124 CAGLIARI,ITALY. IST MED LEGALE AM,I-20129 MILAN,ITALY. OSPED LORETO MARE,I-80100 NAPLES,ITALY. OSPED VECCHIO PELLEGRINI,DIV CHIRURG 3,I-80100 NAPLES,ITALY.
Published online on: September 1, 1995 https://doi.org/10.3892/or.2.5.727
Pages: 727-730

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Abstract

Twenty-two patients with locally advanced inoperable gastric cancer received neoadjuvant chemotherapy with a modified 5-fluorouracil, doxorubicin, methotrexate (FAMTX) regimen. The patients who achieved at least a stable disease were considered eligible for surgery with curative intent, which was performed in 19 cases. 16 patients (all responsive to neoadjuvant chemotherapy) were rendered disease-free by the combined approach. No treatment-related deaths occurred; grade III leukopenia was observed in only 3 cases. The preliminary results of this study indicate the feasibility of our treatment approach; randomized trials are awaited to properly evaluate the role of neoadjuvant chemotherapy in locally advanced gastric cancer.