Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

  • Authors:
    • Yachao Zhao
    • Changliang Zhu
    • Xiaofei Li
    • Zhipei Zhang
    • Yuan Yuan
    • Yunfeng Ni
    • Tonggang Liu
    • Sanming Deng
    • Jinbo Zhao
    • Yunjie Wang
  • View Affiliations

  • Published online on: June 23, 2011     https://doi.org/10.3892/or.2011.1358
  • Pages: 919-924
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Abstract

Asterosaponin 1, a new cytostatic agent from starfish, possesses several bioactivities including an antitumor effect. The aim of this study was to investigate the potential anti-proliferative and pro-apoptotic activity of asterosaponin 1 in A549 human lung cancer cells, as well as the potential mechanisms. The results showed that asterosaponin 1 inhibited the proliferation of A549 cells in a dose-dependent manner, and the cytostatic activity resulted from the induction of apoptotic cell death. Asterosaponin 1 increased ER dilation and cytosolic Ca2+ concentration, and enhanced the expression of the ER molecular chaperones GRP78 and GRP94 in a dose- and time-dependent manner. In addition, asterosaponin 1 treated A549 cells exerted increased expression and activity of CHOP, caspase-4 and JNK, three essential ER-associated apoptotic molecules. In summary, these results demonstrated that asterosaponin 1 inhibits the proliferation of A549 cells through induction of ER stress-associated apoptosis, making asterosaponin 1 a candidate new anticancer drug for lung cancer therapy.

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October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhao Y, Zhu C, Li X, Zhang Z, Yuan Y, Ni Y, Liu T, Deng S, Zhao J, Wang Y, Wang Y, et al: Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells. Oncol Rep 26: 919-924, 2011.
APA
Zhao, Y., Zhu, C., Li, X., Zhang, Z., Yuan, Y., Ni, Y. ... Wang, Y. (2011). Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells. Oncology Reports, 26, 919-924. https://doi.org/10.3892/or.2011.1358
MLA
Zhao, Y., Zhu, C., Li, X., Zhang, Z., Yuan, Y., Ni, Y., Liu, T., Deng, S., Zhao, J., Wang, Y."Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells". Oncology Reports 26.4 (2011): 919-924.
Chicago
Zhao, Y., Zhu, C., Li, X., Zhang, Z., Yuan, Y., Ni, Y., Liu, T., Deng, S., Zhao, J., Wang, Y."Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells". Oncology Reports 26, no. 4 (2011): 919-924. https://doi.org/10.3892/or.2011.1358