1
|
Elmore E, Stringer DE, Steele VE, Gerner
EW and Redpath JL: Chemoprevention by difluoromethylornithine:
correlation of an in vitro human cell assay with human clinical
data for biomarker modulation. Anticancer Res. 21:1163–1165.
2001.PubMed/NCBI
|
2
|
Gerner EW and Meyskens FL Jr: Polyamines
and cancer: old molecules, new understanding. Nat Rev Cancer.
4:781–792. 2004. View
Article : Google Scholar : PubMed/NCBI
|
3
|
Jiang R, Choi W, Khan A, et al: Activation
of polyamine catabolism by
N1,N11-diethylnorspermine leads to cell death
in glioblastoma. Int J Oncol. 31:431–440. 2007.PubMed/NCBI
|
4
|
Pledgie A, Huang Y, Hacker A, et al:
Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is
the primary source of cytotoxic H2O2 in
polyamine analogue-treated human breast cancer cell lines. J Biol
Chem. 280:39843–39851. 2005.PubMed/NCBI
|
5
|
Xu H, Chaturvedi R, Cheng Y, et al:
Spermine oxidation induced by Helicobacter pylori results in
apoptosis and DNA damage: implications for gastric carcinogenesis.
Cancer Res. 64:8521–8525. 2004.PubMed/NCBI
|
6
|
Choi W, Gerner EW, Ramdas L, et al:
Combination of 5-fluorouracil and N1,N11-diethylnorspermine
markedly activates spermidine/spermine N1-acetyltransferase
expression, depletes polyamines, and synergistically induces
apoptosis in colon carcinoma cells. J Biol Chem. 280:3295–3304.
2005. View Article : Google Scholar
|
7
|
Chen Y, Kramer DL, Diegelman P, Vujcic S
and Porter CW: Apoptotic signaling in polyamine analogue-treated
SK-MEL-28 human melanoma cells. Cancer Res. 61:6437–6444.
2001.PubMed/NCBI
|
8
|
Jiang R, Choi W, Hu L, Gerner EW, Hamilton
SR and Zhang W: Activation of polyamine catabolism by
N1,N11-diethylnorspermine alters the cellular
localization of mTOR and downregulates mTOR protein level in
glioblastoma cells. Cancer Biol Ther. 6:1644–1648. 2007.PubMed/NCBI
|
9
|
Ha HC, Woster PM, Yager JD and Casero RA
Jr: The role of polyamine catabolism in polyamine analogue-induced
programmed cell death. Proc Natl Acad Sci USA. 94:11557–11562.
1997. View Article : Google Scholar : PubMed/NCBI
|
10
|
Hegardt C, Johannsson OT and Oredsson SM:
Rapid caspase-dependent cell death in cultured human breast cancer
cells induced by the polyamine analogue
N(1),N(11)-diethylnorspermine. Eur J Biochem. 269:1033–1039. 2002.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Wang Z, Zahedi K, Barone S, et al:
Overexpression of SSAT in kidney cells recapitulates various
phenotypic aspects of kidney ischemia-reperfusion injury. J Am Soc
Nephrol. 15:1844–1852. 2004. View Article : Google Scholar : PubMed/NCBI
|
12
|
Casero RA Jr and Marton LJ: Targeting
polyamine metabolism and function in cancer and other
hyperproliferative diseases. Nat Rev Drug Discov. 6:373–390. 2007.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Porter CW, Ganis B, Libby PR and Bergeron
RJ: Correlations between polyamine analogue-induced increases in
spermidine/spermine N1-acetyltransferase activity, polyamine pool
depletion, and growth inhibition in human melanoma cell lines.
Cancer Res. 51:3715–3720. 1991.
|
14
|
Casero RA Jr, Celano P, Ervin SJ, Wiest L
and Pegg AE: High specific induction of spermidine/spermine
N1-acetyltransferase in a human large cell lung
carcinoma. Biochem J. 270:615–620. 1990.PubMed/NCBI
|
15
|
Allen WL, McLean EG, Boyer J, et al: The
role of spermidine/spermine N1-acetyltransferase in
determining response to chemotherapeutic agents in colorectal
cancer cells. Mol Cancer Ther. 6:128–137. 2007.
|
16
|
Oredsson SM, Alm K, Dahlberg E, et al:
Inhibition of cell proliferation and induction of apoptosis by
N(1),N(11)-diethylnorspermine-induced polyamine pool reduction.
Biochem Soc Trans. 35:405–409. 2007. View Article : Google Scholar : PubMed/NCBI
|
17
|
Casero RA Jr, Mank AR, Xiao L, Smith J,
Bergeron RJ and Celano P: Steady-state messenger RNA and activity
correlates with sensitivity to
N1,N12-bis(ethyl)spermine in human cell lines
representing the major forms of lung cancer. Cancer Res.
52:5359–5363. 1992.PubMed/NCBI
|
18
|
Uhm JH, Gladson CL and Rao JS: The role of
integrins in the malignant phenotype of gliomas. Front Biosci.
4:D188–D199. 1999. View
Article : Google Scholar : PubMed/NCBI
|
19
|
Maglott A, Bartik P, Cosgun S, et al: The
small alpha5beta1 integrin antagonist, SJ749, reduces proliferation
and clonogenicity of human astrocytoma cells. Cancer Res.
66:6002–6007. 2006. View Article : Google Scholar : PubMed/NCBI
|
20
|
Farber K, Synowitz M, Zahn G, et al: An
alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell
Neurosci. 39:579–585. 2008. View Article : Google Scholar : PubMed/NCBI
|
21
|
Kesari S, Ramakrishna N, Sauvageot C,
Stiles CD and Wen PY: Targeted molecular therapy of malignant
gliomas. Curr Neurol Neurosci Rep. 5:186–197. 2005. View Article : Google Scholar : PubMed/NCBI
|
22
|
Capdevila J, Salazar R, Halperin I, Abad A
and Yao JC: Innovations therapy: mammalian target of rapamycin
(mTOR) inhibitors for the treatment of neuroendocrine tumors.
Cancer Metastasis Rev. 30:27–34. 2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Martelli AM, Evangelisti C, Follo MY, et
al: Targeting the phosphatidylinositol 3-kinase/akt/mammalian
target of rapamycin signaling network in cancer stem cells. Curr
Med Chem. 18:2715–2726. 2011. View Article : Google Scholar : PubMed/NCBI
|
24
|
Fan QW, Knight ZA, Goldenberg DD, et al: A
dual PI3-kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer Cell. 9:341–349. 2006. View Article : Google Scholar : PubMed/NCBI
|
25
|
Chen C, Young BA, Coleman CS, Pegg AE and
Sheppard D: Spermidine/spermine N1-acetyltransferase
specifically binds to the integrin alpha9 subunit cytoplasmic
domain and enhances cell migration. J Cell Biol. 167:161–170.
2004.
|
26
|
Ross EA, Douglas MR, Wong SH, et al:
Interaction between integrin alpha9beta1 and vascular cell adhesion
molecule-1 (VCAM-1) inhibits neutrophil apoptosis. Blood.
107:1178–1183. 2006. View Article : Google Scholar : PubMed/NCBI
|
27
|
Taooka Y, Chen J, Yednock T and Sheppard
D: The integrin alpha9beta1 mediates adhesion to activated
endothelial cells and transendothelial neutrophil migration through
interaction with vascular cell adhesion molecule-1. J Cell Biol.
145:413–420. 1999. View Article : Google Scholar
|