Serum interleukin-15 levels in cancer patients with cachexia

  • Authors:
    • Pedro L. Martínez-Hernández
    • Ángel Hernanz-Macías
    • Carmen Gómez-Candela
    • Cristina Grande-Aragón
    • Jaime Feliu-Batlle
    • Javier Castro-Carpeño
    • Isabel Martínez-Muñoz
    • Laura Zurita-Rosa
    • Marta Villarino-Sanz
    • Concepción Prados-Sánchez
    • Joaquín Sánchez García-Girón
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  • Published online on: July 23, 2012     https://doi.org/10.3892/or.2012.1928
  • Pages: 1443-1452
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Abstract

Interleukin-15 (IL-15) has important anabolic effects on muscle protein metabolism through a decrease in the ATP-ubiquitin-dependent proteolytic pathway. The role of IL-15 in human cancer cachexia is unknown. The aim of this study was to assess the relationship between interleukin-15 (IL-15) in cancer patients with cachexia at diagnosis of malignancy and 8 weeks later. An observational study of 21 cancer patients (with and without cachexia) and 8 healthy subjects was conducted. Body composition was measured by leg-to-leg impedance. Serum IL-15 levels were assessed at baseline and after 4 and 8 weeks. Baseline IL-15 values were similar in cancer patients and in healthy subjects. Cancer patients with lower baseline levels of IL-15 (<2 pg/ml) had significantly higher fat mass (%) along the study. Eighteen patients completed the study: five patients showed an increase of 3.7 kg at the end of the study (5.4% of body weight) and showed a mean increase of IL-15 of 1.32 pg/ml (121%) at 4 weeks and 2.32 pg/ml (197%) at 8 weeks, as compared with mean decrease of -4.1 kg (-5.3%) and -0.09 pg/ml (-2.5%) and 0.6 pg/ml (40.8%) in the 13 patients who lost weight (P=0.001 and P=0.022, respectively). Changes of IL-15 at 4 and 8 weeks were directly associated with changes in body weight, body mass index (BMI), fat-free mass and muscle mass (P<0.05), and indirectly associated with percentage of weight loss (P<0.05). In summary, although the results indicate that IL-15 does not have a role in cancer cachexia pathogenesis, the association during evolution between serum IL-15 and changes in weight and muscle mass suggests a possible role of IL-15 as a marker of the body composition response in cancer patients who are losing weight at the time of diagnosis.
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October 2012
Volume 28 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Martínez-Hernández PL, Hernanz-Macías Á, Gómez-Candela C, Grande-Aragón C, Feliu-Batlle J, Castro-Carpeño J, Martínez-Muñoz I, Zurita-Rosa L, Villarino-Sanz M, Prados-Sánchez C, Prados-Sánchez C, et al: Serum interleukin-15 levels in cancer patients with cachexia. Oncol Rep 28: 1443-1452, 2012.
APA
Martínez-Hernández, P.L., Hernanz-Macías, Á., Gómez-Candela, C., Grande-Aragón, C., Feliu-Batlle, J., Castro-Carpeño, J. ... Sánchez García-Girón , J. (2012). Serum interleukin-15 levels in cancer patients with cachexia. Oncology Reports, 28, 1443-1452. https://doi.org/10.3892/or.2012.1928
MLA
Martínez-Hernández, P. L., Hernanz-Macías, Á., Gómez-Candela, C., Grande-Aragón, C., Feliu-Batlle, J., Castro-Carpeño, J., Martínez-Muñoz, I., Zurita-Rosa, L., Villarino-Sanz, M., Prados-Sánchez, C., Sánchez García-Girón , J."Serum interleukin-15 levels in cancer patients with cachexia". Oncology Reports 28.4 (2012): 1443-1452.
Chicago
Martínez-Hernández, P. L., Hernanz-Macías, Á., Gómez-Candela, C., Grande-Aragón, C., Feliu-Batlle, J., Castro-Carpeño, J., Martínez-Muñoz, I., Zurita-Rosa, L., Villarino-Sanz, M., Prados-Sánchez, C., Sánchez García-Girón , J."Serum interleukin-15 levels in cancer patients with cachexia". Oncology Reports 28, no. 4 (2012): 1443-1452. https://doi.org/10.3892/or.2012.1928