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Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells

  • Authors:
    • Dong Xu
    • Xingxing He
    • Ying Chang
    • Chuanrui Xu
    • Xiang Jiang
    • Shuzhen Sun
    • Jusheng Lin

  • View Affiliations

  • Published online on: November 14, 2012     https://doi.org/10.3892/or.2012.2138
  • Pages: 653-661
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Abstract

microRNAs (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Several miRNAs are associated with the development of hepatocellular carcinoma (HCC). miR-96 has been closely associated with cell proliferation and clonogenicity. Upregulation of miR-96 has been observed in various types of cancer. However, the biological function of miR-96 in hepatocarcinogenesis remains largely unknown. In this study, we demonstrated that miR-96 was upregulated in HCC and inhibition of miR-96 significantly suppressed HCC cell proliferation and colony formation. The expression levels of forkhead box O1 (FOXO1) and forkhead box O3a (FOXO3a) were upregulated when miR-96 was inhibited in HCC cells and the inhibition of FOXO1 and FOXO3a promoted HCC cell proliferation and colony formation. Collectively, these data reveal an important contribution of miR-96 to hepatocarcinogenesis and suggest a role for FOXO1 and FOXO3a dysregulation in this process. Thus, the use of a synthetic inhibitor of miR-96 may be a promising approach for the treatment of HCC.
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February 2013
Volume 29 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Xu D, He X, Chang Y, Xu C, Jiang X, Sun S and Lin J: Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells. Oncol Rep 29: 653-661, 2013.
APA
Xu, D., He, X., Chang, Y., Xu, C., Jiang, X., Sun, S., & Lin, J. (2013). Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells. Oncology Reports, 29, 653-661. https://doi.org/10.3892/or.2012.2138
MLA
Xu, D., He, X., Chang, Y., Xu, C., Jiang, X., Sun, S., Lin, J."Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells". Oncology Reports 29.2 (2013): 653-661.
Chicago
Xu, D., He, X., Chang, Y., Xu, C., Jiang, X., Sun, S., Lin, J."Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells". Oncology Reports 29, no. 2 (2013): 653-661. https://doi.org/10.3892/or.2012.2138