|
1
|
Siegel R, Ward E, Brawley O and Jemal A:
Cancer statistics, 2011: the impact of eliminating socioeconomic
and racial disparities on premature cancer deaths. CA Cancer J
Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Wang D, Zheng W, Wang SM, et al:
Estimation of cancer incidence and mortality attributable to
overweight, obesity, and physical inactivity in China. Nutr Cancer.
64:48–56. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Chiva L, Lapuente F, Gonzalez-Cortijo L,
et al: Sparing fertility in young patients with endometrial cancer.
Gynecol Oncol. 111:S101–S104. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Dedes KJ, Wetterskog D, Ashworth A, Kaye
SB and Reis-Filho JS: Emerging therapeutic targets in endometrial
cancer. Nat Rev Clin Oncol. 8:261–271. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Chaudhry P and Asselin E: Resistance to
chemotherapy and hormone therapy in endometrial cancer. Endocr
Relat Cancer. 16:363–380. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kumar R, Gururaj AE and Barnes CJ:
p21-activated kinases in cancer. Nat Rev Cancer. 6:459–471. 2006.
View Article : Google Scholar
|
|
7
|
Eswaran J, Soundararajan M, Kumar R and
Knapp S: UnPAKing the class differences among p21-activated
kinases. Trends Biochem Sci. 33:394–403. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Manser E, Leung T, Salihuddin H, Zhao ZS
and Lim L: A brain serine/threonine protein kinase activated by
Cdc42 and Rac1. Nature. 367:40–46. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Edwards DC, Sanders LC, Bokoch GM and Gill
GN: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase
signalling to actin cytoskeletal dynamics. Nat Cell Biol.
1:253–259. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Wang RA, Mazumdar A, Vadlamudi RK and
Kumar R: P21-activated kinase-1 phosphorylates and transactivates
estrogen receptor-alpha and promotes hyperplasia in mammary
epithelium. EMBO J. 21:5437–5447. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ong CC, Jubb AM, Haverty PM, et al:
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of
tumor cells. Proc Natl Acad Sci USA. 108:7177–7182. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhou H and Kramer RH: Integrin engagement
differentially modulates epithelial cell motility by RhoA/ROCK and
PAK1. J Biol Chem. 280:10624–10635. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Bagheri-Yarmand R, Vadlamudi RK, Wang RA,
Mendelsohn J and Kumar R: Vascular endothelial growth factor
up-regulation via p21-activated kinase-1 signaling regulates
heregulin-beta1-mediated angiogenesis. J Biol Chem.
275:39451–39457. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Vadlamudi RK and Kumar R: P21-activated
kinases in human cancer. Cancer Metastasis Rev. 22:385–393. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Carter JH: Pak-1 expression increases with
progression of colorectal carcinomas to metastasis. Clin Cancer
Res. 10:3448–3456. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Siu MK, Wong ES, Chan HY, et al:
Differential expression and phosphorylation of Pak1 and Pak2 in
ovarian cancer: effects on prognosis and cell invasion. Int J
Cancer. 127:21–31. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Balasenthil S: p21-activated kinase-1
signaling mediates cyclin D1 expression in mammary epithelial and
cancer cells. J Biol Chem. 279:1422–1428. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Rettig M, Trinidad K, Pezeshkpour G, et
al: AK1 kinase promotes cell motility and invasiveness through
CRK-II serine phosphorylation in non-small cell lung cancer cells.
PLoS One. 7:e420122012. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Di Cristofano A and Ellenson LH:
Endometrial carcinoma. Annu Rev Pathol. 2:57–85. 2007.
|
|
20
|
Siu MK, Chan HY, Kong DS, et al:
p21-activated kinase 4 regulates ovarian cancer cell proliferation,
migration, and invasion and contributes to poor prognosis in
patients. Proc Natl Acad Sci USA. 107:18622–18627. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zhang L, Rees MC and Bicknell R: The
isolation and long-term culture of normal human endometrial
epithelium and stroma. Expression of mRNAs for angiogenic
polypeptides basally and on oestrogen and progesterone challenges.
J Cell Sci. 108:323–331. 1995.
|
|
22
|
Osteen KG, Hill GA, Hargrove JT and
Gorstein F: Development of a method to isolate and culture highly
purified populations of stromal and epithelial cells from human
endometrial biopsy specimens. Fertil Steril. 52:965–972.
1989.PubMed/NCBI
|
|
23
|
Stoker M, O’Neill C, Berryman S and Waxman
V: Anchorage and growth regulation in normal and virus-transformed
cells. Int J Cancer. 3:683–693. 1968. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Menendez JA, Vellon L, Colomer R and Lupu
R: Oleic acid, the main monounsaturated fatty acid of olive oil,
suppresses Her-2/neu (erbB-2) expression and synergistically
enhances the growth inhibitory effects of trastuzumab (Herceptin)
in breast cancer cells with Her-2/neu oncogene amplification. Ann
Oncol. 16:359–371. 2005. View Article : Google Scholar
|
|
25
|
Janicke RU, Sprengart ML, Wati MR and
Porter AG: Caspase-3 is required for DNA fragmentation and
morphological changes associated with apoptosis. J Biol Chem.
273:9357–9360. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Qing H, Gong W, Che Y, et al:
PAK1-dependent MAPK pathway activation is required for colorectal
cancer cell proliferation. Tumour Biol. 33:985–994. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Gururaj AE, Rayala SK and Kumar R:
p21-activated kinase signaling in breast cancer. Breast Cancer Res.
7:5–12. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
28
|
Rayala SK: P21-activated kinase 1
regulation of estrogen receptor-alpha activation involves serine
305 activation linked with serine 118 phosphorylation. Cancer Res.
66:1694–1701. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Kumar R: Signaling intricacies take center
stage in cancer cells. Cancer Res. 65:2511–2515. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Gururaj AE: Novel mechanisms of resistance
to endocrine therapy: genomic and nongenomic considerations. Clin
Cancer Res. 12:S1001–S1007. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kok M, Zwart W, Holm C, et al: PKA-induced
phosphorylation of ERα at serine 305 and high PAK1 levels is
associated with sensitivity to tamoxifen in ER-positive breast
cancer. Breast Cancer Res Treat. 125:1–12. 2010.PubMed/NCBI
|
|
32
|
Gimona M: Mechanics and dynamics of the
cytoskeleton: a special issue stemming from the 2008 ECF
Meeting/FEBS Workshop (Mechanics and Dynamics of the Cytoskeleton)
in Potsdam, Germany. Cell Motil Cytoskeleton. 66:ii–iii. 2009.
View Article : Google Scholar
|
|
33
|
Delorme-Walker VD, Peterson JR, Chernoff
J, et al: Pak1 regulates focal adhesion strength, myosin IIA
distribution, and actin dynamics to optimize cell migration. J Cell
Biol. 193:1289–1303. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
McCarty SK, Saji M, Zhang X, et al: Group
I p21-activated kinases regulate thyroid cancer cell migration and
are overexpressed and activated in thyroid cancer invasion. Endocr
Relat Cancer. 17:989–999. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Li LH, Luo Q, Zheng MH, et al:
P21-activated protein kinase 1 is overexpressed in gastric cancer
and induces cancer metastasis. Oncol Rep. 27:1435–1442.
2012.PubMed/NCBI
|
|
36
|
Vadlamudi RK, Adam L, Wang RA, et al:
Regulatable expression of p21-activated kinase-1 promotes
anchorage-independent growth and abnormal organization of mitotic
spindles in human epithelial breast cancer cells. J Biol Chem.
275:36238–36244. 2000. View Article : Google Scholar
|
|
37
|
Vadlamudi RK, Bagheri-Yarmand R, Yang Z,
et al: Dynein light chain 1, a p21-activated kinase 1-interacting
substrate, promotes cancerous phenotypes. Cancer Cell. 5:575–585.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Shrestha Y, Schafer EJ, Boehm JS, et al:
PAK1 is a breast cancer oncogene that coordinately activates MAPK
and MET signaling. Oncogene. 31:3397–3408. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Schurmann A, Mooney AF, Sanders LC, et al:
p21-activated kinase 1 phosphorylates the death agonist bad and
protects cells from apoptosis. Mol Cell Biol. 20:453–461. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Yang X, Zheng F, Xing H, et al: Resistance
to chemotherapy-induced apoptosis via decreased caspase-3 activity
and overexpression of antiapoptotic proteins in ovarian cancer. J
Cancer Res Clin Oncol. 130:423–428. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Szanto A, Bognar Z, Szigeti A, Szabo A,
Farkas L and Gallyas F Jr: Critical role of bad phosphorylation by
Akt in cytostatic resistance of human bladder cancer cells.
Anticancer Res. 29:159–164. 2009.PubMed/NCBI
|
|
42
|
Peiro G, Diebold J, Baretton GB, Kimmig R
and Lohrs U: Cellular apoptosis susceptibility gene expression in
endometrial carcinoma: correlation with Bcl-2, Bax, and caspase-3
expression and outcome. Int J Gynecol Pathol. 20:359–367. 2001.
View Article : Google Scholar : PubMed/NCBI
|
