DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells

  • Authors:
    • Wei Yu
    • Ying-Chen Xu
    • Ying Tao
    • Ping He
    • Yang Li
    • Tao Wu
    • Yan-Pei Zhu
    • Jing Li
    • Ji-Xiang Wu
    • Jie Dai
  • View Affiliations

  • Published online on: October 1, 2013     https://doi.org/10.3892/or.2013.2769
  • Pages: 2741-2748
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Abstract

Decoy receptor 3 (DcR3) is considered to have anti‑apoptotic and pro-metastatic functions, suggesting it might be a therapeutic target. We examined the role and mechanisms of DcR3 on growth and the metastatic ability of SW480 colon cancer cells to provide therapeutic information for targeting DcR3 by RNA interference (RNAi) technology. Growth and the metastatic ability were inhibited, apoptosis was induced and cell cycle profile was changed after decreasing DcR3 expression, with lower levels of vascular endothelial growth factors (VEGFs) and matrix metalloproteinases (MMPs) expression. Our results implied the therapeutic potential of silencing DcR3 expression by RNAi in colon cancer.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yu W, Xu Y, Tao Y, He P, Li Y, Wu T, Zhu Y, Li J, Wu J, Dai J, Dai J, et al: DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells. Oncol Rep 30: 2741-2748, 2013.
APA
Yu, W., Xu, Y., Tao, Y., He, P., Li, Y., Wu, T. ... Dai, J. (2013). DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells. Oncology Reports, 30, 2741-2748. https://doi.org/10.3892/or.2013.2769
MLA
Yu, W., Xu, Y., Tao, Y., He, P., Li, Y., Wu, T., Zhu, Y., Li, J., Wu, J., Dai, J."DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells". Oncology Reports 30.6 (2013): 2741-2748.
Chicago
Yu, W., Xu, Y., Tao, Y., He, P., Li, Y., Wu, T., Zhu, Y., Li, J., Wu, J., Dai, J."DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells". Oncology Reports 30, no. 6 (2013): 2741-2748. https://doi.org/10.3892/or.2013.2769