The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy

  • Authors:
    • Ning Liu
    • Ye Xu
    • Ji-Tong Sun
    • Jing Su
    • Xi-Yan Xiang
    • Hao-Wei Yi
    • Zhi-Chao Zhang
    • Lian-Kun Sun
  • View Affiliations

  • Published online on: October 1, 2013     https://doi.org/10.3892/or.2013.2771
  • Pages: 2677-2684
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Abstract

SKOV3/DDP human ovarian cancer cells have been shown to be resistant to cisplatin. Although the BH3 mimetic S1 induces cell death in several types of tumor cells, it is unclear whether it induces death in drug-resistant cells. Herein, we found that S1 induced endoplasmic reticulum (ER) stress-associated apoptosis in both SKOV3 and SKOV3/DDP cells. S1 activated autophagy at early time points in SKOV3/DDP cells, and inhibition of autophagy increased ER stress-associated apoptosis. Collectively, our data indicate that autophagy plays a protective role, but it cannot protect against S1-induced cell death in cisplatin-resistant SKOV3/DDP cells.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu N, Xu Y, Sun J, Su J, Xiang X, Yi H, Zhang Z and Sun L: The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy. Oncol Rep 30: 2677-2684, 2013.
APA
Liu, N., Xu, Y., Sun, J., Su, J., Xiang, X., Yi, H. ... Sun, L. (2013). The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy. Oncology Reports, 30, 2677-2684. https://doi.org/10.3892/or.2013.2771
MLA
Liu, N., Xu, Y., Sun, J., Su, J., Xiang, X., Yi, H., Zhang, Z., Sun, L."The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy". Oncology Reports 30.6 (2013): 2677-2684.
Chicago
Liu, N., Xu, Y., Sun, J., Su, J., Xiang, X., Yi, H., Zhang, Z., Sun, L."The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy". Oncology Reports 30, no. 6 (2013): 2677-2684. https://doi.org/10.3892/or.2013.2771