Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection

  • Authors:
    • Takeshi Iida
    • Makoto Iwahashi
    • Masahiro Katsuda
    • Koichiro Ishida
    • Mikihito Nakamori
    • Masaki Nakamura
    • Teiji Naka
    • Toshiyasu Ojima
    • Kentaro Ueda
    • Keiji Hayata
    • Hironao Yasuoka
    • Hiroki Yamaue
  • View Affiliations

  • Published online on: December 10, 2013     https://doi.org/10.3892/or.2013.2911
  • Pages: 605-612
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Abstract

Peritoneal dissemination is frequently detected in patients with advanced gastric cancer. The peritoneal cavity is a compartment in which an immunologic host-tumor interaction can occur. There are no reports on the relationship between IL-17 expression in peritoneal lavage and prognosis in gastric cancer patients. Therefore, we investigated the expression of IL-17 mRNA in peritoneal lavage from gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. Peritoneal lavage was obtained from 114 patients with gastric cancer at initial surgery. Seventy-nine patients underwent curative resection. Among these 79 patients, IL-17 mRNA expression was associated with the depth of tumor invasion (p<0.05). Twelve of the 79 patients who underwent curative resection died, and 9 of those 12 developed peritoneal metastasis. Notably, among the 79 patients who underwent curative resection, those with high expression of IL-17 mRNA in peritoneal lavage had significantly prolonged survival when compared to these patients with low expression of IL-17 mRNA in peritoneal lavage (p<0.05) as evidence by the survival curves. In a multivariate analysis, low expression of IL-17 mRNA in peritoneal lavage and tumor size were found to be independent significant predictive factors for prognosis (HR, 7.91; 95% CI, 1.65-38.03) in the patients who underwent curative resection. IL-17 mRNA expression in peritoneal lavage is a reliable prognostic factor for patients undergoing curative resection for gastric cancer. Low IL-17 expression in the peritoneal cavity may correlate with cancer development in the peritoneal cavity in patients with gastric cancer.
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2014-February
Volume 31 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Hayata K, et al: Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection. Oncol Rep 31: 605-612, 2014.
APA
Iida, T., Iwahashi, M., Katsuda, M., Ishida, K., Nakamori, M., Nakamura, M. ... Yamaue, H. (2014). Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection. Oncology Reports, 31, 605-612. https://doi.org/10.3892/or.2013.2911
MLA
Iida, T., Iwahashi, M., Katsuda, M., Ishida, K., Nakamori, M., Nakamura, M., Naka, T., Ojima, T., Ueda, K., Hayata, K., Yasuoka, H., Yamaue, H."Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection". Oncology Reports 31.2 (2014): 605-612.
Chicago
Iida, T., Iwahashi, M., Katsuda, M., Ishida, K., Nakamori, M., Nakamura, M., Naka, T., Ojima, T., Ueda, K., Hayata, K., Yasuoka, H., Yamaue, H."Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection". Oncology Reports 31, no. 2 (2014): 605-612. https://doi.org/10.3892/or.2013.2911