Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival

  • Authors:
    • Anna Skalniak
    • Elżbieta Boratyn
    • Sylwia D. Tyrkalska
    • Irena Horwacik
    • Małgorzata Durbas
    • Maria Łastowska
    • Jolanta Jura
    • Hanna Rokita
  • View Affiliations

  • Published online on: March 11, 2014     https://doi.org/10.3892/or.2014.3076
  • Pages: 2385-2392
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Abstract

The importance of monocyte chemotactic protein-1-induced protein 1 (MCPIP1) in the negative regulation of inflammatory reactions has already been extensively studied. However, its role in cancer is not yet established. We studied MCPIP1 gene expression in primary human neuroblastomas and several neuroblastoma cell lines. Our results showed a lack of MCPIP1 expression in primary neuroblastoma tumors. Moreover, it was found that the low expression of the protein measured in human neuroblastoma cell lines might be important for neuroblastoma survival, since enforced MCPIP1 gene expression in human neuroblastoma BE(2)-C cells caused a significant decrease in neuroblastoma cell viability and proliferation.
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May-2014
Volume 31 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Skalniak A, Boratyn E, Tyrkalska SD, Horwacik I, Durbas M, Łastowska M, Jura J and Rokita H: Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival. Oncol Rep 31: 2385-2392, 2014.
APA
Skalniak, A., Boratyn, E., Tyrkalska, S.D., Horwacik, I., Durbas, M., Łastowska, M. ... Rokita, H. (2014). Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival. Oncology Reports, 31, 2385-2392. https://doi.org/10.3892/or.2014.3076
MLA
Skalniak, A., Boratyn, E., Tyrkalska, S. D., Horwacik, I., Durbas, M., Łastowska, M., Jura, J., Rokita, H."Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival". Oncology Reports 31.5 (2014): 2385-2392.
Chicago
Skalniak, A., Boratyn, E., Tyrkalska, S. D., Horwacik, I., Durbas, M., Łastowska, M., Jura, J., Rokita, H."Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival". Oncology Reports 31, no. 5 (2014): 2385-2392. https://doi.org/10.3892/or.2014.3076