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Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study

  • Authors:
    • Marco Johannes Battista
    • Nina Mantai
    • Isabel Sicking
    • Cristina Cotarelo
    • Veronika Weyer
    • Antje Lebrecht
    • Christine Solbach
    • Marcus Schmidt

  • View Affiliations

  • Published online on: March 11, 2014     https://doi.org/10.3892/or.2014.3079
  • Pages: 2213-2219
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Abstract

The identification of prognostic markers has clinical implications in epithelial ovarian carcinoma (EOC). Here, we studied markers for proliferation (Ki-67), endocrine regulation [progesterone receptor (PR), estrogen receptor (ER)], and invasion [urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1)]. All patients with available follow-up information and EOC tissue, who were treated at our institution between 1997 and 2004, were enrolled in the present study. Expression of Ki-67, PR and ER was determined by immunohistochemical analyses. uPA and PAI-1 antigen levels were determined using enzyme‑linked immunosorbent assays. One hundred and eight patients entered the present study. The median follow-up time was 43.3 (range 11.4-68.0) months. In multivariable Cox regression analyses, Ki-67 expression showed an independent negative impact on disease-free survival (DFS) and overall survival (OS) [hazard ratio (HR) for DFS, 11.5; 95% confidence interval (CI), 2.64-49.7; p=0.001 and HR for OS, 21.2; 95% CI, 9.9-113.1; p<0.001]. After cut-off optimization, PR expression showed an independent positive impact on prognosis (HR for DFS, 0.15; 95% CI, 0.03-0.68; p=0.014 and HR for OS, 0.13; 95% CI, 0.03‑0.68; p=0.016). Furthermore, postoperative residual tumor burden and completeness of chemotherapy determined the prognosis. ER, uPA and PAI-1 were not associated with survival. PR and ER, and postoperative residual tumor burden and tumor stage showed a strong correlation in an explorative Spearman's rank correlation coefficient (rho=0.759 and rho=0.426, respectively). Ki-67 and cut-off optimized PR are independently associated with the prognosis of EOC. Further prospective studies are warranted to confirm these associations and to elucidate the underlying mechanisms.
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May-2014
Volume 31 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Battista MJ, Mantai N, Sicking I, Cotarelo C, Weyer V, Lebrecht A, Solbach C and Schmidt M: Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study. Oncol Rep 31: 2213-2219, 2014.
APA
Battista, M.J., Mantai, N., Sicking, I., Cotarelo, C., Weyer, V., Lebrecht, A. ... Schmidt, M. (2014). Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study. Oncology Reports, 31, 2213-2219. https://doi.org/10.3892/or.2014.3079
MLA
Battista, M. J., Mantai, N., Sicking, I., Cotarelo, C., Weyer, V., Lebrecht, A., Solbach, C., Schmidt, M."Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study". Oncology Reports 31.5 (2014): 2213-2219.
Chicago
Battista, M. J., Mantai, N., Sicking, I., Cotarelo, C., Weyer, V., Lebrecht, A., Solbach, C., Schmidt, M."Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study". Oncology Reports 31, no. 5 (2014): 2213-2219. https://doi.org/10.3892/or.2014.3079