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Article

Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma

  • Authors:
    • Jie Chen
    • Jie Zhang
    • Xi Liu
    • Rui Fang
    • Yueran Zhao
    • Demei Ma
  • View Affiliations / Copyright

    Affiliations: Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, Shandong 250012, P.R. China, Central Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Clinical Medicine, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Obstetrics and Gynecology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
  • Pages: 2601-2610
    |
    Published online on: April 16, 2014
       https://doi.org/10.3892/or.2014.3139
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Abstract

Fibulin-4, a member of the fibulin family of extracellular glycoproteins, is implicated in the progression of a number of types of cancer. However, the function of fibulin-4 in cervical cancer progression remains unexplored. Fibulin-4 mRNA and protein expression levels in normal cervical tissue, cervical intraepithelial neoplasia (CIN), cervical carcinoma, highly invasive subclones and low-invasive subclones were evaluated by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry. Serum fibulin-4 levels in patients with CIN and cervical carcinoma were measured by enzyme-linked immunosorbent assay. To assess the angiogenic properties of fibulin-4, vascular endothelial growth factor (VEGF) expression and tumor microvessel density (MVD) were analyzed in the cervical carcinoma cases by immunohistochemistry. Fibulin-4 expression was upregulated in the cervical carcinoma cases, and was positively correlated with MVD and VEGF expression. Fibulin-4 overexpression and high serum levels were significantly associated with advanced stage, low differentiation, lymph node metastasis, and poor prognosis in patients with cervical cancer. Fibulin-4 expression was also found to be overexpressed in highly invasive subclones when compared with the low-invasive subclones. Fibulin-4 is a newly identified glycoprotein that is overexpressed in cervical carcinoma. Fibulin-4 promotes angiogenesis and is associated with poor prognostic clinicopathologic features. This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Waggoner SE: Cervical cancer. Lancet. 361:2217–2225. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Chen J, Shi D, Liu X, Fang S, Zhang J and Zhao Y: Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis. BMC Cancer. 12:4642012. View Article : Google Scholar : PubMed/NCBI

4 

Rao Y, Wang H, Fan L and Chen G: Silencing MTA1 by RNAi reverses adhesion, migration and invasiveness of cervical cancer cells (SiHa) via altered expression of p53, and E-cadherin/β-catenin complex. J Huazhong Univ Sci Technolog Med Sci. 31:1–9. 2011.PubMed/NCBI

5 

Li Y, Wang W, Wang W, et al: Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma. Gynecol Oncol. 124:112–118. 2012. View Article : Google Scholar : PubMed/NCBI

6 

de Vega S, Iwamoto T and Yamada Y: Fibulins: multiple roles in matrix structures and tissue functions. Cell Mol Life Sci. 66:1890–1902. 2009.PubMed/NCBI

7 

Gallagher WM, Currid CA and Whelan LC: Fibulins and cancer: friend or foe? Trends Mol Med. 11:336–340. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Law EW, Cheung AK, Kashuba VI, et al: Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma. Oncogene. 31:728–738. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Yi CH, Smith DJ, West WW and Hollingsworth MA: Loss of fibulin-2 expression is associated with breast cancer progression. Am J Pathol. 170:1535–1545. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Schluterman MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H and Brekken RA: Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS. Dis Model Mech. 3:333–342. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Hu Z, Ai Q, Xu H, et al: Fibulin-5 is down-regulated in urothelial carcinoma of bladder and inhibits growth and invasion of human bladder cancer cell line 5637. Urol Oncol. 29:430–435. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yue W, Sun Q, Landreneau R, Wu C, Siegfried JM, Yu J and Zhang L: Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res. 69:6339–6346. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Moll F, Katsaros D, Lazennec G, et al: Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells. Oncogene. 21:1097–1107. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Greene LM, Twal WO, Duffy MJ, et al: Elevated expression and altered processing of fibulin-1 protein in human breast cancer. Br J Cancer. 88:871–878. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Bardin A, Moll F, Margueron R, et al: Transcriptional and posttranscriptional regulation of fibulin-1 by estrogens leads to differential induction of messenger ribonucleic acid variants in ovarian and breast cancer cells. Endocrinology. 146:760–768. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Seeliger H, Camaj P, Ischenko I, et al: EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma. Mol Cancer Res. 7:189–198. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Song EL, Hou YP, Yu SP, et al: EFEMP1 expression promotes angiogenesis and accelerates the growth of cervical cancer in vivo. Gynecol Oncol. 121:174–180. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Song EL, Chen SG and Wang HQ: The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis. Gynecol Oncol. 117:417–422. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Hu B, Thirtamara-Rajamani KK, Sim H and Viapiano MS: Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. Mol Cancer Res. 7:1756–1770. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Kanda M, Nomoto S, Okamura Y, Hayashi M, Hishida M, Fujii T, Nishikawa Y, Sugimoto H, Takeda S and Nakao A: Promoter hypermethylation of fibulin 1 gene is associated with tumor progression in hepatocellular carcinoma. Mol Carcinog. 50:571–579. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Cheng YY, Jin H, Liu X, et al: Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer. Br J Cancer. 99:2083–2087. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Wlazlinski A, Engers R, Hoffmann MJ, et al: Downregulation of several fibulin genes in prostate cancer. Prostate. 67:1770–1780. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Xie L, Palmsten K, MacDonald B, et al: Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med. 233:155–162. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Hwang CF, Chien CY, Huang SC, et al: Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity. J Pathol. 222:367–379. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Sadr-Nabavi A, Ramser J, Volkmann J, et al: Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer. 124:1727–1735. 2009. View Article : Google Scholar

26 

Hu Y, Pioli PD, Siegel E, et al: EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. Mol Cancer. 10:1232011. View Article : Google Scholar : PubMed/NCBI

27 

Kim EJ, Lee SY, Woo MK, et al: Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation. Int J Oncol. 40:402–408. 2012.PubMed/NCBI

28 

Chen L, Sun B, Zhang S, et al: Influence of microenvironments on microcirculation patterns and tumor invasion-related protein expression in melanoma. Oncol Rep. 21:917–923. 2009.PubMed/NCBI

29 

Argraves WS, Greene LM, Cooley MA and Gallagher WM: Fibulins: physiological and disease perspectives. EMBO Rep. 4:1127–1131. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Berk DR, Bentley DD, Bayliss SJ, Lind A and Urban Z: Cutis laxa: a review. J Am Acad Dermatol. 66:842.e1–17. 2012.PubMed/NCBI

31 

Huang J, Yamashiro Y, Papke CL, et al: Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice. Sci Transl Med. 5:183ra581–11. 2013.PubMed/NCBI

32 

Xiang Y, Sekine T, Nakamura H, et al: Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis. J Immunol. 176:3196–3204. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Gallagher WM, Greene LM, Ryan MP, Sierra V, Berger A, Laurent-Puig P and Conseiller E: Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues. FEBS Lett. 489:59–66. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Ying J, Shan L, Li J, et al: Genome-wide screening for genetic alterations in esophageal cancer by aCGH identifies 11q13 amplification oncogenes associated with nodal metastasis. PLoS One. 7:e397972012. View Article : Google Scholar : PubMed/NCBI

35 

Ormandy CJ, Musgrove EA, Hui R, Daly RJ and Sutherland RL: Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat. 78:323–335. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M and Sugihara K: Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res. 10:8465–8471. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Weidner N, Folkman J, Pozza F, et al: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 84:1875–1887. 1992. View Article : Google Scholar : PubMed/NCBI

38 

Landis JR and Koch GG: The measurement of observer agreement for categorical data. Biometrics. 33:159–174. 1977. View Article : Google Scholar : PubMed/NCBI

39 

McLaughlin PJ, Chen Q, Horiguchi M, et al: Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol. 26:1700–1709. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Weis SM and Cheresh DA: Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 17:1359–1370. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Yanagisawa H, Schluterman MK and Brekken RA: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal. 3:337–347. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Albig AR, Neil JR and Schiemann WP: Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. Cancer Res. 66:2621–2629. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Henrotin Y, Gharbi M, Mazzucchelli G, Dubuc JE, De Pauw E and Deberg M: Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis. Arthritis Rheum. 64:2260–2267. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Pass HI, Levin SM, Harbut MR, et al: Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma. N Engl J Med. 367:1417–1427. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Piura E and Piura B: Autoantibodies to tumor-associated antigens in breast carcinoma. J Oncol. 2010:2649262010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Zhang J, Liu X, Fang R, Zhao Y and Ma D: Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep 31: 2601-2610, 2014.
APA
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., & Ma, D. (2014). Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncology Reports, 31, 2601-2610. https://doi.org/10.3892/or.2014.3139
MLA
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., Ma, D."Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma". Oncology Reports 31.6 (2014): 2601-2610.
Chicago
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., Ma, D."Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma". Oncology Reports 31, no. 6 (2014): 2601-2610. https://doi.org/10.3892/or.2014.3139
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Zhang J, Liu X, Fang R, Zhao Y and Ma D: Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncol Rep 31: 2601-2610, 2014.
APA
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., & Ma, D. (2014). Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma. Oncology Reports, 31, 2601-2610. https://doi.org/10.3892/or.2014.3139
MLA
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., Ma, D."Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma". Oncology Reports 31.6 (2014): 2601-2610.
Chicago
Chen, J., Zhang, J., Liu, X., Fang, R., Zhao, Y., Ma, D."Overexpression of fibulin-4 is associated with tumor progression and poor prognosis in patients with cervical carcinoma". Oncology Reports 31, no. 6 (2014): 2601-2610. https://doi.org/10.3892/or.2014.3139
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