Open Access

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)

  • Authors:
    • Hilda Jiménez-Wences
    • Oscar Peralta-Zaragoza
    • Gloria Fernández-Tilapa
  • View Affiliations

  • Published online on: April 16, 2014     https://doi.org/10.3892/or.2014.3142
  • Pages: 2467-2476
  • Copyright: © Jiménez-Wences et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect gene expression. The progression from precursor lesions to invasive cervical cancer is influenced by persistent human papilloma virus (HPV) infection, which induces changes in the host genome and epigenome. Epigenetic alterations, such as aberrant miRNA expression and changes in DNA methylation status, favor the expression of oncogenes and the silencing of tumor-suppressor genes. Given that some miRNA genes can be regulated through epigenetic mechanisms, it has been proposed that alterations in the methylation status of miRNA promoters could be the driving mechanism behind their aberrant expression in cervical cancer. For these reasons, we assessed the relationship among HPV infection, cellular DNA methylation and miRNA expression. We conclude that alterations in the methylation status of protein-coding genes and various miRNA genes are influenced by HPV infection, the viral genotype, the physical state of the viral DNA, and viral oncogenic risk. Furthermore, HPV induces deregulation of miRNA expression, particularly at loci near fragile sites. This deregulation occurs through the E6 and E7 proteins, which target miRNA transcription factors such as p53.
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June-2014
Volume 31 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jiménez-Wences H, Peralta-Zaragoza O and Fernández-Tilapa G: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep 31: 2467-2476, 2014.
APA
Jiménez-Wences, H., Peralta-Zaragoza, O., & Fernández-Tilapa, G. (2014). Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncology Reports, 31, 2467-2476. https://doi.org/10.3892/or.2014.3142
MLA
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31.6 (2014): 2467-2476.
Chicago
Jiménez-Wences, H., Peralta-Zaragoza, O., Fernández-Tilapa, G."Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review)". Oncology Reports 31, no. 6 (2014): 2467-2476. https://doi.org/10.3892/or.2014.3142