Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)

  • Authors:
    • Jianhong Zhu
    • Handong Wang
    • Youwu Fan
    • Yixing Lin
    • Li  Zhang
    • Xiangjun Ji
    • Mengliang Zhou
  • View Affiliations

  • Published online on: June 12, 2014     https://doi.org/10.3892/or.2014.3259
  • Pages: 443-450
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Abstract

Glioblastoma is the most common and malignant subtype among all brain tumors. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular defense against a variety of endogenous and exogenous stresses. A marked increase in research over the past few decades focusing on Nrf2 and its role in regulating glioblastoma has revealed the potential value of Nrf2 in the treatment of glioblastoma. In the present review, we discuss a novel framework of Nrf2 in the regulation of glioblastoma and the mechanisms regarding the downregulation of Nrf2 in treating glioblastoma. The candidate mechanisms include direct and indirect means. Direct mechanisms target tumor molecular pathways in order to overcome resistance to chemotherapy and radiotherapy, to inhibit proliferation, to block invasion and migration, to induce apoptosis, to promote differentiation, to enhance autophagy and to target glioblastoma stem cells. Indirect mechanisms target the reaction between glioblastoma cells and the surrounding microenvironment. Overall, the value of the Nrf2 pathway in glioblastoma provides a promising opportunity for new approaches by which to treat glioblastoma.
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August-2014
Volume 32 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu J, Wang H, Fan Y, Lin Y, Zhang L, Ji X and Zhou M: Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review). Oncol Rep 32: 443-450, 2014.
APA
Zhu, J., Wang, H., Fan, Y., Lin, Y., Zhang, L., Ji, X., & Zhou, M. (2014). Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review). Oncology Reports, 32, 443-450. https://doi.org/10.3892/or.2014.3259
MLA
Zhu, J., Wang, H., Fan, Y., Lin, Y., Zhang, L., Ji, X., Zhou, M."Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)". Oncology Reports 32.2 (2014): 443-450.
Chicago
Zhu, J., Wang, H., Fan, Y., Lin, Y., Zhang, L., Ji, X., Zhou, M."Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)". Oncology Reports 32, no. 2 (2014): 443-450. https://doi.org/10.3892/or.2014.3259