Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma

  • Authors:
    • Junhye Kwon
    • Hyeon-Joon Yoon
    • Ji-Hee Kim
    • Tae Sup Lee
    • In Ho Song
    • Hae Won Lee
    • Moon Chul Kang
    • Jong Ho Park
  • View Affiliations

  • Published online on: July 3, 2014     https://doi.org/10.3892/or.2014.3302
  • Pages: 1188-1192
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Abstract

A malignant esophageal cancer, squamous cell carcinoma is one of the most prevalent cancers. Despite the use of present surgical techniques combined with various treatment modalities, the overall 5-year survival rate remains at 15-34%. Epidermal growth factor receptor (EGFR) is the most well studied receptor in various cancers and EGFR overexpression is detected in 40% of esophageal squamous cell carcinomas (ESCCs) and ESCC cell lines. To examine the EGFR antibody combination effect, we used treatment with cisplatin and cetuximab in ESCC cell lines, TE-4 and TE-8. Combination of cetuximab and cisplatin resulted in a growth inhibition only in the EGFR overexpressed TE-8 cell line. Furthermore, we confirmed that cisplatin-induced EGFR activation was inhibited by cetuximab in TE-8 but not in TE-4 cells. Our data suggest that cetuximab combined with cisplatin exerts antitumorigenic effects in vitro and in vivo via suppression of EGF signaling, which can be applied toward targeted ESCC treatments.
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September-2014
Volume 32 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kwon J, Yoon H, Kim J, Lee TS, Song IH, Lee HW, Kang MC and Park JH: Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma. Oncol Rep 32: 1188-1192, 2014.
APA
Kwon, J., Yoon, H., Kim, J., Lee, T.S., Song, I.H., Lee, H.W. ... Park, J.H. (2014). Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma. Oncology Reports, 32, 1188-1192. https://doi.org/10.3892/or.2014.3302
MLA
Kwon, J., Yoon, H., Kim, J., Lee, T. S., Song, I. H., Lee, H. W., Kang, M. C., Park, J. H."Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma". Oncology Reports 32.3 (2014): 1188-1192.
Chicago
Kwon, J., Yoon, H., Kim, J., Lee, T. S., Song, I. H., Lee, H. W., Kang, M. C., Park, J. H."Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma". Oncology Reports 32, no. 3 (2014): 1188-1192. https://doi.org/10.3892/or.2014.3302