Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells

  • Authors:
    • Guojun Wang
    • Yanwei Ye
    • Xiefu Zhang
    • Junmin Song
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  • Published online on: July 30, 2014     https://doi.org/10.3892/or.2014.3366
  • Pages: 1709-1714
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Abstract

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. In the present study, we investigated a possible role of BK in colorectal cancer cell invasion and migration. Invasion and migration assays showed that BK treatment promoted the invasion and migration of colorectal cancer cells. Further experiments showed that BK treatment stimulated ERK1/2 activation and IL-6 production. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), were significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuated the BK-mediated invasion and migration, and inhibited ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreased the BK-mediated IL-6 production. In addition, IL-6 repression suppressed the effects of BK on colorectal cancer cell invasion and migration. Taken together, the present study demonstrated that BK increases IL-6 production via B2R and the ERK pathway, thereby contributing to the invasion and migration of colorectal cancer cells. Thus, our findings may provide benefits for the treatment of colorectal cancer.
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October 2014
Volume 32 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang G, Ye Y, Zhang X and Song J: Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep 32: 1709-1714, 2014.
APA
Wang, G., Ye, Y., Zhang, X., & Song, J. (2014). Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncology Reports, 32, 1709-1714. https://doi.org/10.3892/or.2014.3366
MLA
Wang, G., Ye, Y., Zhang, X., Song, J."Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells". Oncology Reports 32.4 (2014): 1709-1714.
Chicago
Wang, G., Ye, Y., Zhang, X., Song, J."Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells". Oncology Reports 32, no. 4 (2014): 1709-1714. https://doi.org/10.3892/or.2014.3366