Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer

  • Authors:
    • Feng Jiao
    • Hai Hu
    • Cuncun Yuan
    • Lei Wang
    • Weihua Jiang
    • Ziliang Jin
    • Zhen Guo
    • Liwei Wang
  • View Affiliations

  • Published online on: September 26, 2014     https://doi.org/10.3892/or.2014.3518
  • Pages: 2485-2492
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Abstract

Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) correlate with several solid tumors. However, the underlying molecular mechanisms and its clinical significance in pancreatic cancer remain to be elucidated. In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Consistently, higher expression level of MALAT-1 was found in all seven pancreatic cancer cell lines relative to the human pancreatic ductal epithelial cell. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. The underlying mechanisms are possibly involved in inducing G2/M cell cycle arrest, promoting cell apoptosis, suppressing epithelial-mesenchymal transition and reducing cancer stem-like properties. In conclusion, this study indicated that MALAT-1 may serve as an oncogenic lncRNA that is involved in malignancy phenotypes of pancreatic cancer. Therefore, it may be used as a potential therapeutic target.
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December-2014
Volume 32 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jiao F, Hu H, Yuan C, Wang L, Jiang W, Jin Z, Guo Z and Wang L: Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer. Oncol Rep 32: 2485-2492, 2014.
APA
Jiao, F., Hu, H., Yuan, C., Wang, L., Jiang, W., Jin, Z. ... Wang, L. (2014). Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer. Oncology Reports, 32, 2485-2492. https://doi.org/10.3892/or.2014.3518
MLA
Jiao, F., Hu, H., Yuan, C., Wang, L., Jiang, W., Jin, Z., Guo, Z., Wang, L."Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer". Oncology Reports 32.6 (2014): 2485-2492.
Chicago
Jiao, F., Hu, H., Yuan, C., Wang, L., Jiang, W., Jin, Z., Guo, Z., Wang, L."Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer". Oncology Reports 32, no. 6 (2014): 2485-2492. https://doi.org/10.3892/or.2014.3518