miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma

  • Authors:
    • Jiye Feng
    • Jinbo Wang
    • Mingliang Chen
    • Gun Chen
    • Zongyang Wu
    • Liping Ying
    • Qifeng Zhuo
    • Jianlei Zhang
    • Weilin Wang
  • View Affiliations

  • Published online on: December 2, 2014     https://doi.org/10.3892/or.2014.3642
  • Pages: 713-720
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

miR-200a suppresses tumor development and progression; however, its role in tumor growth and metastasis of hepatocellular carcinoma (HCC) and the underlying mechanism have not been elucidated. In the present study, we identified that miR-200a was markedly downregulated in HCC and exerted suppressive effects on tumor cell growth and metastasis. We identified that miR-200a suppressed tumor growth and metastasis by directly targeting MACC1. In addition, HCC patients with low miR-200a expression had significantly worse prognosis than those with high expression of miR-200a. These findings suggest that miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation.
View Figures
View References

Related Articles

Journal Cover

February-2015
Volume 33 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Wang J, Chen M, Chen G, Wu Z, Ying L, Zhuo Q, Zhang J and Wang W: miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncol Rep 33: 713-720, 2015.
APA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L. ... Wang, W. (2015). miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncology Reports, 33, 713-720. https://doi.org/10.3892/or.2014.3642
MLA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33.2 (2015): 713-720.
Chicago
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33, no. 2 (2015): 713-720. https://doi.org/10.3892/or.2014.3642