MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer

  • Authors:
    • Lin Tang
    • Feng Chen
    • Er-Jun Pang
    • Zhi-Qi Zhang
    • Bing-Wei Jin
    • Wei-Feng Dong
  • View Affiliations

  • Published online on: February 12, 2015     https://doi.org/10.3892/or.2015.3798
  • Pages: 1707-1716
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Abstract

MicroRNA-182 (miR-182) is significantly downregulated in human gastric tissue samples. Overexpression of miR-182 suppresses the proliferation and colony formation of gastric cancer cells. However, new aspects of the mechanism are still emerging in gastric cancer. ANUBL1, also known as ZFAND4 (zinc finger, AN1-type domain 4), its roles are scarely reported in cancer. In this study, we not only showed that ANUBL1 as an oncogene was upregulated and could promote proliferation of SGC-7901 cells, but also demonstrated that its over­expression led to a strong decrease of miR-182 expression and expression of ANUBL1 was in turn directly downregulated by miR-182, thereby establishing a negative feedback loop between miR-182 and ANUBL1. The elucidation of the mechanisms of miR-182 targeting ANUBL1 in gastric cancer helps us to further understand the mechanism of gastric cancer initiation and progression.
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April-2015
Volume 33 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Tang L, Chen F, Pang E, Zhang Z, Jin B and Dong W: MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Oncol Rep 33: 1707-1716, 2015.
APA
Tang, L., Chen, F., Pang, E., Zhang, Z., Jin, B., & Dong, W. (2015). MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Oncology Reports, 33, 1707-1716. https://doi.org/10.3892/or.2015.3798
MLA
Tang, L., Chen, F., Pang, E., Zhang, Z., Jin, B., Dong, W."MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer". Oncology Reports 33.4 (2015): 1707-1716.
Chicago
Tang, L., Chen, F., Pang, E., Zhang, Z., Jin, B., Dong, W."MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer". Oncology Reports 33, no. 4 (2015): 1707-1716. https://doi.org/10.3892/or.2015.3798