Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review)

  • Authors:
    • Ye-Seul Kim
    • Kyung-A Hwang
    • Ryeo-Eun Go
    • Cho-Won Kim
    • Kyung-Chul Choi
  • View Affiliations

  • Published online on: March 10, 2015     https://doi.org/10.3892/or.2015.3846
  • Pages: 2107-2112
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Abstract

There are three types of stem cells: embryonic stem (ES) cells, adult stem (AS) cells and induced pluripotent stem (iPS) cells. These stem cells have many benefits including the potential ability to differentiate into various organs. In addition, engineered stem cells (GESTECs) designed for delivering therapeutic genes may be capable of treating human diseases including malignant cancers. Stem cells have been found to possess the potential for serving as novel delivery vehicles for therapeutic or suicide genes to primary or metastatic cancer formation sites as a part of gene-directed enzyme/prodrug combination therapy (GEPT). Given the advantageous properties of stem cells, tissue-derived stem cells are emerging as a new tool for anticancer therapy combined with prodrugs. In this review, the effects of GESTECs with different origins, i.e., neural, amniotic membrane and amniotic fluid, introduced to treat patients with diverse types of gynecologic and breast cancers are discussed. Data from the literature indicate the therapeutic potential of these cells as a part of gene therapy strategies to selectively target malignancies in women at clinically terminal stages.
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May-2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Kim Y, Hwang K, Go R, Kim C and Choi K: Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review). Oncol Rep 33: 2107-2112, 2015.
APA
Kim, Y., Hwang, K., Go, R., Kim, C., & Choi, K. (2015). Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review). Oncology Reports, 33, 2107-2112. https://doi.org/10.3892/or.2015.3846
MLA
Kim, Y., Hwang, K., Go, R., Kim, C., Choi, K."Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review)". Oncology Reports 33.5 (2015): 2107-2112.
Chicago
Kim, Y., Hwang, K., Go, R., Kim, C., Choi, K."Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review)". Oncology Reports 33, no. 5 (2015): 2107-2112. https://doi.org/10.3892/or.2015.3846