Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death

  • Authors:
    • Uddin Md. Nazim
    • Jae-Kyo Jeong
    • Jae-Won Seol
    • Jin Hur
    • Seong-Kug Eo
    • John-Hwa Lee
    • Sang-Youel Park
  • View Affiliations

  • Published online on: March 20, 2015     https://doi.org/10.3892/or.2015.3869
  • Pages: 2331-2336
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Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a primary anticancer agent and a member of the tumor necrosis factor family that selectively induces apoptosis in various tumor cells, but not in normal cells. Gingerol is a major ginger component with anti-inflammatory and anti‑tumorigenic activities. Autophagy flux is the complete process of autophagy, in which the autophagosomes are lysed by lysosomes. The role of autophagy in cell death or cell survival is controversial. A549 adenocarcinoma cells are TRAIL-resistant. In the present study, we showed that treatment with TRAIL slightly induced cell death, but gingerol treatment enhanced the TRAIL-induced cell death in human lung cancer cells. The combination of gingerol and TRAIL increased accumulation of microtubule-associated protein light chain 3-II and p62, confirming the inhibited autophagy flux. Collectively, our results suggest that gingerol sensitizes human lung cancer cells to TRAIL-induced apoptosis by inhibiting the autophagy flux.
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May-2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nazim UM, Jeong J, Seol J, Hur J, Eo S, Lee J and Park S: Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death. Oncol Rep 33: 2331-2336, 2015.
APA
Nazim, U.M., Jeong, J., Seol, J., Hur, J., Eo, S., Lee, J., & Park, S. (2015). Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death. Oncology Reports, 33, 2331-2336. https://doi.org/10.3892/or.2015.3869
MLA
Nazim, U. M., Jeong, J., Seol, J., Hur, J., Eo, S., Lee, J., Park, S."Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death". Oncology Reports 33.5 (2015): 2331-2336.
Chicago
Nazim, U. M., Jeong, J., Seol, J., Hur, J., Eo, S., Lee, J., Park, S."Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death". Oncology Reports 33, no. 5 (2015): 2331-2336. https://doi.org/10.3892/or.2015.3869