1
|
Jung KW, Won YJ, Oh CM, Kong HJ, Cho H,
Lee DH and Lee KH: Prediction of cancer incidence and mortality in
Korea, 2015. Cancer Res Treat. 47:142–148. 2015. View Article : Google Scholar : PubMed/NCBI
|
2
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
|
3
|
Jung KW, Won YJ, Kong HJ, Oh CM, Cho H,
Lee DH and Lee KH: Cancer statistics in Korea: Incidence,
mortality, survival, and prevalence in 2012. Cancer Res Treat.
47:127–141. 2015. View Article : Google Scholar : PubMed/NCBI
|
4
|
Govindan R, Page N, Morgensztern D, Read
W, Tierney R, Vlahiotis A, Spitznagel EL and Piccirillo J: Changing
epidemiology of small-cell lung cancer in the United States over
the last 30 years: Analysis of the surveillance, epidemiologic, and
end results database. J Clin Oncol. 24:4539–4544. 2006. View Article : Google Scholar : PubMed/NCBI
|
5
|
Kang JA, Yang Z, Lee JY, De U, Kim TH,
Park JY, Lee HJ, Park YJ, Chun P, Kim HS, et al: Design, synthesis
and anticancer activity of novel
dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives. Bioorg
Med Chem Lett. 21:5730–5734. 2011. View Article : Google Scholar : PubMed/NCBI
|
6
|
Hwang HJ, Kang YJ, Hossain MA, Kim DH,
Jang JY, Lee SH, Yoon JH, Moon HR, Kim HS, Chung HY, et al: Novel
dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449,
induces apoptosis and cell cycle arrest in HCT116 human colon
cancer cells. Int J Oncol. 41:2057–2064. 2012.PubMed/NCBI
|
7
|
Lee SH, Kang YJ, Sung B, Kim DH, Lim HS,
Kim HR, Kim SJ, Yoon JH, Moon HR, Chung HY, et al: MHY-449, a novel
dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces
apoptotic cell death through modulation of Akt/FoxO1 and ERK
signaling in PC3 human prostate cancer cells. Int J Oncol.
44:905–911. 2014.PubMed/NCBI
|
8
|
Kroemer G and Reed JC: Mitochondrial
control of cell death. Nat Med. 6:513–519. 2000. View Article : Google Scholar : PubMed/NCBI
|
9
|
Yamada T, Takeuchi S, Fujita N, Nakamura
A, Wang W, Li Q, Oda M, Mitsudomi T, Yatabe Y, Sekido Y, et al: Akt
kinase-interacting protein1, a novel therapeutic target for lung
cancer with EGFR-activating and gatekeeper mutations. Oncogene.
32:4427–4435. 2013. View Article : Google Scholar
|
10
|
Zhou L, Luan H, Liu Q, Jiang T, Liang H,
Dong X and Shang H: Activation of PI3K/Akt and ERK signaling
pathways antagonized sinomenine-induced lung cancer cell apoptosis.
Mol Med Rep. 5:1256–1260. 2012.PubMed/NCBI
|
11
|
Lee MW, Kim DS, Lee JH, Lee BS, Lee SH,
Jung HL, Sung KW, Kim HT, Yoo KH and Koo HH: Roles of AKT1 and AKT2
in non-small cell lung cancer cell survival, growth, and migration.
Cancer Sci. 102:1822–1828. 2011. View Article : Google Scholar : PubMed/NCBI
|
12
|
Chandarlapaty S, Sawai A, Scaltriti M,
Rodrik-Outmezguine V, Grbovic-Huezo O, Serra V, Majumder PK,
Baselga J and Rosen N: AKT inhibition relieves feedback suppression
of receptor tyrosine kinase expression and activity. Cancer Cell.
19:58–71. 2011. View Article : Google Scholar : PubMed/NCBI
|
13
|
Puglisi M, Thavasu P, Stewart A, de Bono
JS, O'Brien ME, Popat S, Bhosle J and Banerji U: AKT inhibition
synergistically enhances growth-inhibitory effects of gefitinib and
increases apoptosis in non-small cell lung cancer cell lines. Lung
Cancer. 85:141–146. 2014. View Article : Google Scholar : PubMed/NCBI
|
14
|
Taylor RC, Cullen SP and Martin SJ:
Apoptosis: Controlled demolition at the cellular level. Nat Rev Mol
Cell Biol. 9:231–241. 2008. View
Article : Google Scholar
|
15
|
Chang HY and Yang X: Proteases for cell
suicide: Functions and regulation of caspases. Microbiol Mol Biol
Rev. 64:821–846. 2000. View Article : Google Scholar : PubMed/NCBI
|
16
|
Tait SW and Green DR: Mitochondria and
cell death: Outer membrane permeabilization and beyond. Nat Rev Mol
Cell Biol. 11:621–632. 2010. View
Article : Google Scholar : PubMed/NCBI
|
17
|
Kantari C and Walczak H: Caspase-8 and
bid: Caught in the act between death receptors and mitochondria.
Biochim Biophys Acta. 1813:558–563. 2011. View Article : Google Scholar : PubMed/NCBI
|
18
|
Gross A, McDonnell JM and Korsmeyer SJ:
BCL-2 family members and the mitochondria in apoptosis. Genes Dev.
13:1899–1911. 1999. View Article : Google Scholar : PubMed/NCBI
|
19
|
Stambolic V, Suzuki A, de la Pompa JL,
Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM,
Siderovski DP and Mak TW: Negative regulation of PKB/Akt-dependent
cell survival by the tumor suppressor PTEN. Cell. 95:29–39. 1998.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Kennedy SG, Wagner AJ, Conzen SD, Jordán
J, Bellacosa A, Tsichlis PN and Hay N: The PI 3-kinase/Akt
signaling pathway delivers an anti-apoptotic signal. Genes Dev.
11:701–713. 1997. View Article : Google Scholar : PubMed/NCBI
|
21
|
Kim D, Cheng GZ, Lindsley CW, Yang H and
Cheng JQ: Targeting the phosphatidylinositol-3 kinase/Akt pathway
for the treatment of cancer. Curr Opin Investig Drugs. 6:1250–1258.
2005.PubMed/NCBI
|
22
|
Dinavahi SS, Prasanna R, Dharmarajan S,
Perumal Y and Viswanadha S: A novel, potent, small molecule AKT
inhibitor exhibits efficacy against lung cancer cells in vitro.
Cancer Res Treat. Jan 2–2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI
|
23
|
Vasudevan KM, Gurumurthy S and Rangnekar
VM: Suppression of PTEN expression by NF-kappa B prevents
apoptosis. Mol Cell Biol. 24:1007–1021. 2004. View Article : Google Scholar : PubMed/NCBI
|
24
|
Jung IL, Kang HJ, Kim KC and Kim IG:
PTEN/pAkt/p53 signaling pathway correlates with the radioresponse
of non-small cell lung cancer. Int J Mol Med. 25:517–523.
2010.PubMed/NCBI
|