Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation

  • Authors:
    • Jun Huang
    • Zhen-Hua Chen
    • Chun-Mei Ren
    • Dong-Xu Wang
    • Shuang‑Xue Yuan
    • Qiu-Xiang Wu
    • Qian-Zhao Chen
    • Yu-Hua Zeng
    • Ying Shao
    • Yang Li
    • Ke Wu
    • Yu Yu
    • Wen-Juan Sun
    • Bai-Cheng He
  • View Affiliations

  • Published online on: September 24, 2015     https://doi.org/10.3892/or.2015.4309
  • Pages: 3203-3211
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Abstract

Colon cancer is one of the most common malignancies. Although the current treatment regimes for colon cancer have been well-developed in the past decades, the prognosis remains still undesirable. It is still urgent to explore new treatment strategies for colon cancer. Natural products is one of the most useful sources for anticancer agents, although some of them have serious side-effects. Evodiamine (Evo) is an quinolone alkaloid from the traditional herb medicine Evodia rutaecarpa. In the present study, we investigated the anticancer effect of Evo in human colon cancer cells. We found that Evo exhibits prominent antiproliferation and apoptosis inducing effects in LoVo cells. Evo leads to apparent downregulation of HIF-1α either in vitro or in vivo; exogenous expression of HIF-1α can attenuate the antiproliferation effect of Evo in LoVo cells, while HIF-1α knockdown potentiates this effect greatly. Further analysis indicated that Evo can also inhibit the phosphorylation of Akt1/2/3 and decrease greatly the expression of IGF-1. Thus, our findings strongly suggested that the anticancer effect of Evo in human colon cancer may be partly mediated by downregulating HIF-1α expression, which is initiated by inactivating PI3K/Akt signaling transduction though decreasing the expression of IGF-1 in colon cancer cells. Therefore, Evo may be used alone or in combination as a potential anticancer agent for colon cancer treatment.
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December-2015
Volume 34 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Huang J, Chen Z, Ren C, Wang D, Yuan SX, Wu Q, Chen Q, Zeng Y, Shao Y, Li Y, Li Y, et al: Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation. Oncol Rep 34: 3203-3211, 2015.
APA
Huang, J., Chen, Z., Ren, C., Wang, D., Yuan, S., Wu, Q. ... He, B. (2015). Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation. Oncology Reports, 34, 3203-3211. https://doi.org/10.3892/or.2015.4309
MLA
Huang, J., Chen, Z., Ren, C., Wang, D., Yuan, S., Wu, Q., Chen, Q., Zeng, Y., Shao, Y., Li, Y., Wu, K., Yu, Y., Sun, W., He, B."Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation". Oncology Reports 34.6 (2015): 3203-3211.
Chicago
Huang, J., Chen, Z., Ren, C., Wang, D., Yuan, S., Wu, Q., Chen, Q., Zeng, Y., Shao, Y., Li, Y., Wu, K., Yu, Y., Sun, W., He, B."Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation". Oncology Reports 34, no. 6 (2015): 3203-3211. https://doi.org/10.3892/or.2015.4309